Abstract
In the present study, microwave-mediated Green chemistry approach is followed to prepare some chalcone derivatives. For this purpose, microwave heating technology is used as the alternative energy sources to synthesize a series of chalcone derivatives by Claisen-Schmidt condensation of ethyl 4-acetamidobenzoate with various aromatic aldehydes in the presence of ethanolic sodium hydroxide solution followed by dehydration. With the help of microwave, the rate of reaction is increased with less byproduct formation and better yield of the product. The structures of the newly synthesized compounds are confirmed by FT-IR, H-1 NMR, mass spectra and CHN analyses. The titled compounds are screened for their anthelmintic activity and significant activity as compared to the standard drug is found. Compounds with electron withdrawing groups are found to be highly potent among the series.