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Microwave mediated syntheses of beta-enamino thioic acid derivatives
Journal article   Open access  Peer reviewed

Microwave mediated syntheses of beta-enamino thioic acid derivatives

Alan R. Katritzky, Hui Tao and Kostyantyn Kirichenko
ARKIVOC free online journal of organic chemistry, Vol.2007(10), pp.142-151
25/02/2007

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Reaction of di(benzotriazole-1-yl) methanethione 1 with imines 2a-f gave air and moisture stable benzotriazolyl beta-enaminothiones 3a-f. The thioacylbenzotriazoles 3a-f enable simple and efficient preparation of beta-enamino thioic acid derivatives (thioamides, thioesters and dithioesters) in 74-99% yields via microwave mediated nucleophilic substitution of the benzotriazolyl moiety. C-Thioacylation with 1-thioacyl-6-nitrobenzotriazoles 7a-c is also discussed.
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https://doi.org/10.3998/ark.5550190.0008.a12View
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