Abstract
Herein, we report a new, simple, one pot and chemoselective method for N‐methylation and N,N‐dimethylation of aliphatic and aromatic amines under ambient conditions using NHC‐borane i.e 1,3‐dimethylimidazole‐2‐ylidene borane (diMe‐Imd‐BH3), as reducing agent. The present strategy has significant advantages like mild reaction conditions, quick and effortless work‐up processes, and the use of non‐toxic inexpensive reagents. The amines with acid‐sensitive moieties are also methylated successfully.
Herein we report the 1,3‐Dimethylimidazole‐2‐ylidene borane (diMe‐Imd‐BH3) as a mild, inexpensive, and chemoselective reagent for reductive N‐methylation of aliphatic and aromatic amines. The protocol is specially designed for the methylation of acid‐sensitive compounds like sugars.