Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Zhiqiang Weng; Huaifeng Li; Weiming He; Liang-Feng Yao; Jianwei Tan; Jinfa Chen; Yaofeng Yuan; Kuo-Wei Huang

doi:10.1016/j.tet.2011.12.085

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Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Journal article

Peer reviewed

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Zhiqiang Weng, Huaifeng Li, Weiming He, Liang-Feng Yao, Jianwei Tan, Jinfa Chen, Yaofeng Yuan and Kuo-Wei Huang

Tetrahedron, Vol.68(11), pp.2527-2531

18/03/2012

DOI: https://doi.org/10.1016/j.tet.2011.12.085

Abstract

Copper catalyst

Terminal alkyne

Trifluoromethylation reaction

A catalytic process for trifluoromethylation of terminal alkynes with Togni’s reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. [Display omitted]

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Title: Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent
Creators - without role: Zhiqiang Weng - Fuzhou University
Huaifeng Li - King Abdullah University of Science and Technology
Weiming He - Fuzhou University
Liang-Feng Yao - King Abdullah University of Science and Technology
Jianwei Tan - Fuzhou University
Jinfa Chen - Fuzhou University
Yaofeng Yuan - Fuzhou University
Kuo-Wei Huang - King Abdullah University of Science and Technology
Publication Details: Tetrahedron, Vol.68(11), pp.2527-2531
Publisher: Elsevier Ltd
Identifiers: 9944856408331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article