Abstract
Background: Semicarbazide (SE) is a known food additive that can be found both in nature and in manufactured glass containers. Unfortunately, it has deleterious effects on both animals and human.
Methods: Male juvenile rats were divided into four experimental groups: control group, TU group, SE group, and SE +TU group. In addition to the histological examination, blood total triiodothyronine (T3), total thyroxine (T4), testosterone levels, histological picture of testis, as well as the expression of caspase-3 and Bax were investigated.
Results: The administration of SE caused many damages, including weight loss, decrease in testes weight, and histopathological damages in the testicular tissue. In contrast, the combined administration of SE +TU restored the T3, T4, and testosterone levels as well as improved the histological testicular profile.
Conclusion: Therefore, it is concluded that TU was able to mitigate the deleterious effects of SE.