Abstract
The activities of the drug-metabolizing enzymes, aniline 4-hydroxylase, benzphetamine
N-demethylase and 7-ethoxycoumarin
O-deethylase have been measured in vitro in kidneys and duodenum of camels (
Camelus dromedarius), guinea pigs (
Cavia porcellus) and rats (
Rattus norvegicus). In these species, levels of hepatic microsomal parameters namely microsomal protein, cytochrome
P
450, cytochrome
b
5 and NADPH–cytochrome
c reductase have also been determined. In general, camels seemed to have the lowest enzyme activity when compared to rats and guinea pigs. Rats showed the highest activity in NADPH–cytochrome
c reductase, aniline 4-hydroxylase and ethoxycoumarin
O-deethylase among these species. However, guinea pigs showed the highest enzyme activity in cytochrome
P
450, cytochrome
b
5 and benzphetamine
N-demethylase.