Abstract
Aggregation as well as thermodynamic behavior of amphiphilic imipramine hydrochloride (IMH) drug (antidepressant) and anionic surfactant (sodium dodecyl sulfate [NaDS] as well as sodium dodecylbenzenesulfonate [NaDBS]) mixtures as a function of solution composition in aqueous solutions have been evaluated by conductometry method at different temperatures. Surfactant (NaDS and NaDBS) employed in the current study is anionic in nature. Various theoretical models such as Clint, Rubingh, Motomura, and Rodenas were employed to gain information regarding the type of interaction between the components in the solution mixtures. The value of micellar mole fraction evaluated by different utilized models is found to be more for IMH‐NaDBS mixtures in comparison with IMH‐NaDS mixtures, signifying that participation of NaDBS is more in mixed micelles as compared with NaDS. Owing to the different charge of employed drug and surfactant, which sources high synergistic results in the mixed system comparative to the possessions of their pure compounds, means here anionic surfactants were elected in favor of the quantitation of cationic drug. The value of interaction parameters (β) was also evaluated by employing the Rubingh's model. The values of Gibbs free energy (∆G0m) for all systems attained to be negative in all studied systems showing that the systems are spontaneous in nature.
Micellization as well as thermodynamic behavior of imipramine hydrochloride (IMH) drug and anionic surfactants mixtures have been evaluated by conductometry method at different temperatures. Various theoretical models such as Clint, Rubingh, Motomura, and Rodenas were used to gain information regarding the type of interaction between the components in the solution mixtures. The values of Gibbs free energy (ΔG0m) for all systems attained to be negative in all studied systems showing that the systems are spontaneous in nature. Effect of temperature and mole fraction (α1) of NaDS on the variations of excess free energy of IMH‐NaDS mixture. The models used were Rubingh (filled symbols), Motomura (open symbols), and Rodenas (half‐filled symbols)