Abstract
The present work carried out a study on transition metal ion complexes which have been synthesized from 2-acetylpyridine N-4-(2-pyridyl) thiosemicarbazone (HAPT) 1. These complexes namely [Zn(HAPT)Cl-2] 2, [Mn (HAPT)Cl-2] 3, [Co (HAPT)Cl-2] 4, [Fe(APT)Cl-2(H2O)] 5 and [UO2(HAPT)(OAc)(2)] 6, were characterized by elemental analysis, spectral (IR, H-1 NMR and UV-vis) and magnetic moment measurements. Thermal properties and decomposition kinetics of all compounds are investigated. The interpretation, mathematical analysis and evaluation of kinetic parameters (E, A, Delta H, Delta S and Delta G) of all thermal decomposition stages have been evaluated using Coats-Redfern equation. The biochemical studies showed that, complexes 3 and 6 have powerful and complete degradation effect on the both DNA and protein. The SOD-like activity exhibited that complex 3 has a strong antioxidative properties. The antibacterial screening demonstrated that, the free ligand (HAPT), complexes 2, 3 and 6 have the maximum and broad activities against Gram-positive and Gram-negative bacterial strains. (C) 2009 Elsevier B. V. All rights reserved.