Abstract
The objective of the current investigation was to explore the reno-protective impact of 70% methanolic extract of Saussura lappa (coustus) against oxidative stress and oxidative DNA fragmentation induced renal damage in rat models in response to chronic exposure to the pesticide, deltamethrin. Deltamethrin was administered orally to rats at two doses (1/15 LD50 and 1/30 LD50) daily for 28 days. The results illustrated that oral intake of S lappa extract (300mg/Kg b.w) for 28 consecutive days to animals ingested by either of the two doses, significantly modulated the elevation in plasma malondialdehyde (MDA) and protein carbonyl as well as the decreases in plasma antioxidants markers, including protein thiol, glutathione S transferase (GST), catalase (CAT) and, superoxide dismutase (SOD) compared with control animal group. The plant extract could also reverse the inhibitory effect of deltamethrin on plasma ATPase in animals intoxicated by either of the two doses. In addition, the plant extract successfully modulated the oxidative DNA damage in kidneys of deltamethrin intoxicated rat groups. The beneficial renoprotective impact of the S lappa extract against deltamethrin toxicity was reflected by improvement in plasma renal function markers (urea and creatinine) and histomorphological pictures of renal tissues.
Conclusion: The current investigation may suggest that early administration of S lappa extract may protect renal tissue from oxidative damage promoted by the toxic effects of deltamethrin pesticide.