Abstract
Diabetes is also known as a critical and noisy disease. Hyperglycemia, that is, increased blood glucose level is a common effect of uncontrolled diabetes, and over a period of time can cause serious effects on health such as blood vessel damage and nervous system damage. However, many attempts have been made to find suitable and beneficial solutions to overcome diabetes. Considering this fact, we synthesized a novel series of indoline-2,3-dione-based benzene sulfonamide derivatives and evaluated them against alpha-glucosidase and alpha-amylase enzymes. Out of the synthesized sixteen compounds (1-16), only three compounds showed better results; the IC50 value was in the range of 12.70 +/- 0.20 to 0.90 +/- 0.10 mu M for alpha-glucosidase against acarbose 11.50 +/- 0.30 mu M and 14.90 +/- 0.20 to 1.10 +/- 0.10 mu M for alpha-amylase against acarbose 12.20 +/- 0.30 mu M. Among the series, only three compounds showed better inhibitory potential such as analogues 11 (0.90 +/- 0.10 mu M for alpha-glucosidase and 1.10 +/- 0.10 mu M for alpha-amylase), 1 (1.10 +/- 0.10 mu M for alpha-glucosidase and 1.30 +/- 0.10 mu M for alpha-amylase), and 6 (1.20 +/- 0.10 mu M for alpha-glucosidase and 1.60 +/- 0.10 mu M for alpha-amylase). Molecular modeling was performed to determine the binding affinity of active interacting residues against these enzymes, and it was found that benzenesulfonohydrazide derivatives can be indexed as suitable inhibitors for diabetes mellitus.