Molecular characterization of a new human coxsackievirus B2 associated with severe hand-foot-mouth disease in Yunnan Province of China in 2012

Jie Zhang; Haihao Zhang; Yilin Zhao; Chen Guo; Zhaoqing Yang; Shaohui Ma; Essam Hassan Ibrahim

doi:10.1007/s00705-016-3075-5

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Molecular characterization of a new human coxsackievirus B2 associated with severe hand-foot-mouth disease in Yunnan Province of China in 2012

Journal article

Peer reviewed

Molecular characterization of a new human coxsackievirus B2 associated with severe hand-foot-mouth disease in Yunnan Province of China in 2012

Jie Zhang, Haihao Zhang, Yilin Zhao, Chen Guo, Zhaoqing Yang, Shaohui Ma and Essam Hassan Ibrahim

Archives of virology, Vol.162(1), pp.307-311

01/2017

DOI: https://doi.org/10.1007/s00705-016-3075-5

PMID: 27709402

Abstract

Child, Preschool

China

Cluster Analysis

Enterovirus B, Human - classification

Enterovirus B, Human - genetics

Enterovirus B, Human - isolation & purification

Genome, Viral

Genotype

Hand, Foot and Mouth Disease - complications

Hand, Foot and Mouth Disease - virology

Humans

Male

Meningitis, Aseptic - virology

Phylogeny

Recombination, Genetic

RNA, Viral - genetics

Sequence Analysis, DNA

Sequence Homology, Nucleic Acid

Human coxsackievirus B2 (CVB2) belongs to the species Human enterovirus B and can cause aseptic meningitis, myocarditis and hand-foot-mouth disease (HFMD). We first determined the complete genome of the RW41-2/YN/CHN/2012 strain, isolated from a patient with HFMD and aseptic meningitis in the Yunnan Province, China in 2012. The strain shared 83.5 % and 82.2 % nucleotide similarity with CVB2 prototype strain Ohio-1, in the complete VP1 gene and the complete genome, respectively. Using phylogenetic and homogeneity analyses for the complete VP1 gene, CVB2 strains could be divided into four genogroups (A-D); the RW41-2/YN/CHN/2012 strain belonging to genogroup D. The amino acid sequence of VP1 is highly conserved. Recombination analyses showed the newly isolated RW41-2/YN/CHN/2012 strain was probably a recombinant, which was closely related to strain CVB2 (KM386639) in the genomic P1 and P2 regions and strains of other human enterovirus B (HEV-B) viruses (KT353721, JX644073, and KP262053) in the P3 region.

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Title: Molecular characterization of a new human coxsackievirus B2 associated with severe hand-foot-mouth disease in Yunnan Province of China in 2012
Creators - without role: Jie Zhang - Chinese Academy of Medical Sciences & Peking Union Medical College
Haihao Zhang - Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), Kunming, China
Yilin Zhao - Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), Kunming, China
Chen Guo - Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), Kunming, China
Zhaoqing Yang - Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), Kunming, China
Shaohui Ma - Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College (CAMS and PUMC), Kunming, China
Essam Hassan Ibrahim - King Khalid University
Publication Details: Archives of virology, Vol.162(1), pp.307-311
Identifiers: 9924244208331
Academic Unit: King Khalid University
Language: English
Resource Type: Journal article