Abstract
Crz1p regulates Calcineurin, a serine-threonine-specific protein phosphatase, in Rhizoctonia solani. It has attracted consideration as a novel
target of antifungal therapy based on studies in numerous pathogenic fungi, including, Cryptococcus neoformans, Candida albicans and
Aspergillus fumigatus. To investigate whether Calcineurin can be a useful target for the treatment of Crz1 protein in R. solani causing wet
root rot in Chickpea. The work presented here reports the in-silico studies of Crz1 protein against natural compounds. This study
Comprises of quantitative structure-toxicity relationship (QSTR) and quantitative structure-activity relationship (QSAR). All compounds
showed high binding energy for Crz1 protein through molecular docking. Further, a pharmacokinetic study revealed that these
compounds had minimal side effects. Biological activity spectrum prediction of these compounds showed potential antifungal properties
by showing significant interaction with Crz1. Hence, these compounds can be used for the prevention and treatment of wet root rot in
Chickpea.