Abstract
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•Synthesis of 18 Quinolinyl-Oxadiazole Hybrids.•In-vitro leishmanicidal potential.•Fully characterized by 1H NMR, 13C NMR and HREI-MS spectroscopic.•In silico analysis were also performed to probe the mode of action.
The high potential of quinoline containing natural products and their derivatives in medicinal chemistry led us to discover a novel series of compounds 6–23 based on the concept of molecular hybridization. Most of the synthesized analogues exhibited potent leishmanicidal potential. The most potent compound (23, IC50=0.10±0.001μM) among the series was found ∼70 times more lethal than the standard drug. The current series 6–23 conceded in the development of fourteen (14) extraordinarily active compounds against leishmaniasis. In silico analysis were also performed to probe the mode of action while all the compounds structure were established by NMR and Mass spectral analysis.