Abstract
Novel pyrrolo[2,3-
d]pyrimidine derivatives
4a–
e,
10,
14,
15, pyrazolopyrrolopyrimidine
13, pyrrolotriazolopyrimidine
5–
9,
17 and pyrrolopyrimidotriazine
18 are reported herein. The design of these compounds was based upon the molecular modeling simulation of the fitting values and conformational energy values of the best-fitted conformers to VEGFRTK inhibitor hypothesis. This hypothesis was generated from its corresponding lead compounds using CATALYST software. The structures of these compounds were confirmed by microanalyses, IR,
1H NMR, and mass spectral data. Compounds
6 and
15 showed interesting in vitro antitumor activity compared to doxorubicin as positive control. These results are nearly consistent with the molecular modeling studies. Docking studies were made on compound
15 to predict its binding mode. Moreover, compound
10 exhibited a significant radioprotective activity.