Abstract
Trimolecular salt Michael adducts 2a-c were synthesized in excellent yields up to 92 % via one-pot multicomponent reactions in an aqueous medium. The chemical structures of compounds 2a-c were characterized by X-ray single-crystal diffraction techniques. Calculations of the density functional theory for the synthesized compound were performed. The stability of the products was deduced by TGA analysis. Compounds 2a-c were screened in vitro for different bio-assays such as thymidine phosphorylase inhibition assay, urease inhibition assay, beta-glucuronidase inhibition assays and cytotoxicity against PC-3 and HeLa cell lines.