Abstract
A total of 120 non-consecutive MRSA isolates were obtained from hospitalized patients at Hospital Kuala Lumpur, Malaysia. All isolates were subjected to antimicrobial susceptibility tests and genotyping based on staphylococcal cassette chromosome mec(SCCmec), Staphylococcus aureus protein A typing (spa) and multilocus sequence typing (MLST). Vast majority of MRSA isolates were resistant to more than three classes of antibiotics. Five antibiotic resistance profiles were observed among the MRSA isolates. All isolates tested were still susceptible to vancomycin. Genotyping revealed isolates are highly clonal, where all MRSA belonged to the predominant Asian clone ST239 comprising 4 spa types. Spa typing revealed four different spa types. Continuous monitoring and effective therapeutic options for Asian MRSA clone is recommended.