Abstract
Image 1
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Low doses of
Moringa oleifera
leaf (MOL) extract increased the cell viability of SaOS-2 cells and primary osteoblasts.
•
High doses decreased the growth, resulting in ROS production and chromatin condensation and cell cycle arrest.
•
Small doses increased the ALP levels, mineralization, and BMP2 and Runx2 genes expression, and
vice versa
.
•
In silico
analysis showed good binding interaction of active components of MOL with BMP2 and Runx2 proteins.
•
The biphasic dose-response of MOL and
in silico
analysis may provide an implication for prospective drug development.