MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

Giovanni Landoni; Vladimir Lomivorotov; Antonio Pisano; Caetano Nigro Neto; Umberto Benedetto; Giuseppe Biondi Zoccai; Marco Gemma; Samuele Frassoni; Felice Eugenio Agrò; Massimo Baiocchi; Filomena R. Barbosa Gomes Galas; Andrei Bautin; Nikola Bradic; Cristiana Carollo; Giuseppe Crescenzi; Abeer M. Elnakera; Mohamed R. El-Tahan; Evgeny Fominskiy; Ahmed G. Farag; Gordana Gazivoda; Stefano Gianni; Evgeny Grigoryev; Fabio Guarracino; Sidik Hanafi; Weiqing Huang; Gudrun Kunst; Jan Kunstyr; Chong Lei; Rosalba Lembo; Zhi-jian Li; Valery Likhvantsev; Andrey Lozovskiy; Jun Ma; Fabrizio Monaco; Paolo Navalesi; Bukamal Nazar; Vadim Pasyuga; Elena Porteri; Colin Royse; Laura Ruggeri; Hynek Riha; Fernanda Santos Silva; Luca Severi; Vladimir Shmyrev; Nikolay Uvaliev; Cheng Bin Wang; Chew-Yin Wang; Dario Winterton; Chow-Yen Yong; Jingui Yu; Rinaldo Bellomo; Alberto Zangrillo

doi:10.1016/j.cct.2017.05.011

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MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

Journal article

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MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design

Giovanni Landoni, Vladimir Lomivorotov, Antonio Pisano, Caetano Nigro Neto, Umberto Benedetto, Giuseppe Biondi Zoccai, Marco Gemma, Samuele Frassoni, Felice Eugenio Agrò, Massimo Baiocchi, …

Contemporary clinical trials, Vol.59, pp.38-43

01/08/2017

DOI: https://doi.org/10.1016/j.cct.2017.05.011

PMID: 28533194

Abstract

Cardiac anesthesia

Cardiac surgery

Intensive care

Randomized trial

Total intravenous anesthesia

Volatile anesthetics

There is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable. Single blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio. Tertiary and University hospitals. Patients (n=10,600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia. The primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality; 30-day death or non-fatal myocardial infarction (composite endpoint); cardiac mortality at 30day and at one year; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two-sided alpha error of 0.05, and a power of 0.9. The trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery.

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Title: MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design
Creators - without role: Giovanni Landoni - Vita-Salute San Raffaele University
Vladimir Lomivorotov - Siberian Biomedical Research Center, Department of Anesthesiology and Intensive Care, Novosibirsk, Russia
Antonio Pisano - Ospedale Monaldi
Caetano Nigro Neto - Anesthesia Section of Cardiothoracic Surgery, Dante Pazzanese Institute of Cardiology, Sao Paulo, Brazil
Umberto Benedetto - NIHR Bristol Cardiovascular Biomedical Research Unit
Giuseppe Biondi Zoccai - Sapienza University of Rome
Marco Gemma - Vita-Salute San Raffaele University
Samuele Frassoni - Vita-Salute San Raffaele University
Felice Eugenio Agrò - Università Campus Bio-Medico
Massimo Baiocchi - Policlinico S.Orsola-Malpighi
Filomena R. Barbosa Gomes Galas - Anesthesia and Intensive care, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil
Andrei Bautin - Federal Almazov North-West Medical Research Centre
Nikola Bradic - University Hospital Dubrava
Cristiana Carollo - University of Padua
Giuseppe Crescenzi - IRCCS Humanitas Research Hospital
Abeer M. Elnakera - Zagazig University
Mohamed R. El-Tahan - King Fahd Hospital of the University
Evgeny Fominskiy - Ministry of Health of the Russian Federation
Ahmed G. Farag - King Abdullah Medical City
Gordana Gazivoda - Institute for Cardiovascular Diseases of Vojvodina
Stefano Gianni - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Evgeny Grigoryev - Ministry of Health of the Russian Federation
Fabio Guarracino - Department of Anaesthesia and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana, Via Paradisa 2, 56123 Pisa, Italy
Sidik Hanafi - Sarawak General Hospital
Weiqing Huang - Wuhan Asia Heart Hospital
Gudrun Kunst - King's College Hospital NHS Foundation Trust
Jan Kunstyr - General University Hospital in Prague
Chong Lei - Air Force Medical University
Rosalba Lembo - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Zhi-jian Li - Second Xiangya Hospital of Central South University
Valery Likhvantsev - Anesthesiology and Intensive Care Department, Moscow Clinical Regional Research Institute, Shepkina st., 61/2, Moscow, Russia
Andrey Lozovskiy - Ural Institute of Cardiology
Jun Ma - Policlinico S.Orsola-Malpighi
Fabrizio Monaco - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Paolo Navalesi - Magna
Bukamal Nazar - Cardiothoracic ICU and Anaesthesia, MKCC, West Riffa, Bahrain
Vadim Pasyuga - Department of Cardiac Aneasthesia and Intensive Care, Astrakhan Federal Centre for Cardiac Surgery, Astrakhan, Russia
Elena Porteri - Dipartimento Cardiotoracico, Azienda Ospedaliera Spedali Civili, Brescia, Italy
Colin Royse - University of Melbourne
Laura Ruggeri - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Hynek Riha - Cardiothoracic Anesthesiology and Intensive Care, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Fernanda Santos Silva - Hospital de Santa Maria
Luca Severi - Azienda Ospedaliera San Camillo-Forlanini
Vladimir Shmyrev - Siberian Biomedical Research Center, Department of Anesthesiology and Intensive Care, Novosibirsk, Russia
Nikolay Uvaliev - Acibadem City Clinic
Cheng Bin Wang - Capital Medical University
Chew-Yin Wang - Anaesthesia and Intensive Care, University of Malaya, Kuala Lumpur, Malaysia
Dario Winterton - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Chow-Yen Yong - Hospital Pulau Pinang
Jingui Yu - Qilu Hospital of Shandong University
Rinaldo Bellomo - University of Melbourne
Alberto Zangrillo - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Publication Details: Contemporary clinical trials, Vol.59, pp.38-43
Publisher: Elsevier Inc
Identifiers: 9915963908331
Academic Unit: Imam Abdulrahman Bin Faisal University
Language: English
Resource Type: Journal article