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Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles
Journal article   Peer reviewed

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles

Remani Vasudevan Sumesh, Muthumani Muthu, Abdulrahman I Almansour, Raju Suresh Kumar, Natarajan Arumugam, S Athimoolam, E Arockia Jeya Yasmi Prabha and Raju Ranjith Kumar
ACS combinatorial science, Vol.18(5), pp.262-270
09/05/2016
DOI: https://doi.org/10.1021/acscombsci.6b00003
PMID: 27027478

Abstract

Azo Compounds Combinatorial Chemistry Techniques - methods Cycloaddition Reaction - methods Heterocyclic Compounds - chemical synthesis Quinolines - chemical synthesis Small Molecule Libraries - chemical synthesis Spiro Compounds Stereoisomerism Thiosemicarbazones
The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline-pyrrolidine/pyrrolothiazole/indolizine-oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives.

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