Abstract
The composite of 2-Cyanoimino-6-aryl-4-(6-methoxynaphthalen-2-yl)-3,4-dihydro-1 H-pyrimidines using 6-methoxy-2-naphthaldehyde and cyanoguanidine in the medium of aqueous sodium hydroxide in ethanol was documented. The structural designations for the aforementioned compounds were made using their spectra, which comprised Mass, FT-IR, 1H and 13C NMR. In vitro-antimicrobial testing of synthetic cyanoimino pyrimidines revealed strong antimicrobial activity against specific bacteria. The antibacterial activity data showed that compound 4 G had the strongest effect on Gram negative bacteria which is K.Pneumoniae whose minimum inhibitory concentration (MIC) is 28. Further, molecular docking studies were analyzed against synthetic cyanoimino pyrimidines to compare the experimental results. Also, produced good hydrogen bonding interactions.
All data generated or analyzed during this study are included in this published article.
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•Multicomponent strategy was adapted to synthesis the same cyanoimino pyrimidine central core with different side chain.•In vitro-antimicrobial testing of synthetic cyanoimino pyrimidines revealed strong antimicrobial activity against specific bacteria.•The molecular docking score of designed compounds has predicted − 8.9 kcal/mol and inhibition constant is 0.30 µM.