Abstract
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•Utilization of Q-Tubes™ as a safe pressure reactor.•Conducting multicomponent reactions under pressure.•Synthesis of benzo[c]chromen-6-one and phenanthridin-6(5H)-one derivatives.
Acetophenone derivatives were reacted with ethyl cyanoacetate, sulfur, and alkynes to yield either benzo[c]chromen-6-ones or phenantheridin-6(5H)-ones. The multicomponent reaction takes place under increased pressure utilizing Q-Tubes™ as a safe reactor to enhance the reaction rate.