Multiethnic Meta-Analysis of Genome-Wide Association Studies in > 100 000 Subjects Identifies 23 FibrinogenAssociated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

Maria Sabater-Lleal; Jie Huang; Daniel Chasman; Silvia Naitza; Abbas Dehghan; Andrew D. Johnson; Alexander Teumer; Alex P. Reiner; Lasse Folkersen; Saonli Basu; Alicja R. Rudnicka; Stella Trompet; Anders Malarstig; Jens Baumert; Joshua C. Bis; Xiuqing Guo; Jouke J. Hottenga; So-Youn Shin; Lorna M. Lopez; Jari Lahti; Toshiko Tanaka; Lisa R. Yanek; Tiphaine Oudot-Mellakh; James F. Wilson; Pau Navarro; Jennifer E. Huffman; Tatijana Zemunik; Susan Redline; Reena Mehra; Drazen Pulanic; Igor Rudan; Alan F. Wright; Ivana Kolcic; Ozren Polasek; Sarah H. Wild; Harry Campbell; J. David Curb; Robert Wallace; Simin Liu; Charles B. Eaton; Diane M. Becker; Lewis C. Becker; Stefania Bandinelli; Katri Raikkonen; Elisabeth Widen; Aarno Palotie; Myriam Fornage; David Green; Myron Gross; Gail Davies; Sarah E. Harris; David C. Liewald; John M. Starr; Frances M. K. Williams; Peter J. Grant; Timothy D. Spector; Rona J. Strawbridge; Angela Silveira; Bengt Sennblad; Fernando Rivadeneira; Andre G. Uitterlinden; Oscar H. Franco; Albert Hofman; Jenny van Dongen; Gonneke Willemsen; Dorret I. Boomsma; Jie Yao; Nancy Swords Jenny; Talin Haritunians; Barbara McKnight; Thomas Lumley; Kent D. Taylor; Jerome I. Rotter; Bruce M. Psaty; Annette Peters; Christian Gieger; Thomas Illig; Anne Grotevendt; Georg Homuth; Henry Voelzke; Thomas Kocher; Anuj Goel; Maria Grazia Franzosi; Udo Seedorf; Robert Clarke; Maristella Steri; Kirill V. Tarasov; Serena Sanna; David Schlessinger; David J. Stott; Naveed Sattar; Brendan M. Buckley; Ann Rumley; Gordon D. Lowe; Wendy L. McArdle; Ming-Huei Chen; Geoffrey H. Tofler; Jaejoon Song; Eric Boerwinkle; Aaron R. Folsom; Lynda M. Rose; Anders Franco-Cereceda; Martina Teichert; M. Arfan Ikram; Thomas H. Mosley; Steve Bevan; Martin Dichgans; Peter M. Rothwell; Cathie L. M. Sudlow; Jemma C. Hopewell; John C. Chambers; Danish Saleheen; Jaspal S. Kooner; John Danesh; Christopher P. Nelson; Jeanette Erdmann; Muredach P. Reilly; Sekar Kathiresan; Heribert Schunkert; Pierre-Emmanuel Morange; Luigi Ferrucci; Johan G. Eriksson; David Jacobs; Ian J. Deary; Nicole Soranzo; Jacqueline C. M. Witteman; Eco J. C. de Geus; Russell P. Tracy; Caroline Hayward; Wolfgang Koenig; Francesco Cucca; J. Wouter Jukema; Per Eriksson; Sudha Seshadri; Hugh S. Markus; Hugh Watkins; Nilesh J. Samani; Henri Wallaschofski; Nicholas L. Smith; David Tregouet; Paul M. Ridker; Weihong Tang; David P. Strachan; Anders Hamsten; Christopher J. O'Donnell; VTE Consortium; Panos Deloukas

doi:10.1161/CIRCULATIONAHA.113.002251

Back

Multiethnic Meta-Analysis of Genome-Wide Association Studies in > 100 000 Subjects Identifies 23 FibrinogenAssociated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

Journal article

Open access

Peer reviewed

Multiethnic Meta-Analysis of Genome-Wide Association Studies in > 100 000 Subjects Identifies 23 FibrinogenAssociated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

Maria Sabater-Lleal, Jie Huang, Daniel Chasman, Silvia Naitza, Abbas Dehghan, Andrew D. Johnson, Alexander Teumer, Alex P. Reiner, Lasse Folkersen, Saonli Basu, …

Circulation (New York, N.Y.), Vol.128(12), pp.1310-1324

17/09/2013

DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.002251

PMID: 23969696

Abstract

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Peripheral Vascular Disease

Science & Technology

Background Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (<2%) of its variation. Methods and Results We conducted a meta-analysis of 28 genome-wide association studies including >90 000 subjects of European ancestry, the first genome-wide association meta-analysis of fibrinogen levels in 7 studies in blacks totaling 8289 samples, and a genome-wide association study in Hispanics totaling 1366 samples. Evaluation for association of single-nucleotide polymorphisms with clinical outcomes included a total of 40 695 cases and 85 582 controls for coronary artery disease, 4752 cases and 24 030 controls for stroke, and 3208 cases and 46 167 controls for venous thromboembolism. Overall, we identified 24 genome-wide significant (P<5x10(-8)) independent signals in 23 loci, including 15 novel associations, together accounting for 3.7% of plasma fibrinogen variation. Gene-set enrichment analysis highlighted key roles in fibrinogen regulation for the 3 structural fibrinogen genes and pathways related to inflammation, adipocytokines, and thyrotrophin-releasing hormone signaling. Whereas lead single-nucleotide polymorphisms in a few loci were significantly associated with coronary artery disease, the combined effect of all 24 fibrinogen-associated lead single-nucleotide polymorphisms was not significant for coronary artery disease, stroke, or venous thromboembolism. Conclusions We identify 23 robustly associated fibrinogen loci, 15 of which are new. Clinical outcome analysis of these loci does not support a causal relationship between circulating levels of fibrinogen and coronary artery disease, stroke, or venous thromboembolism.

Files and links (1)

url

https://doi.org/10.1161/CIRCULATIONAHA.113.002251View

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: Multiethnic Meta-Analysis of Genome-Wide Association Studies in > 100 000 Subjects Identifies 23 FibrinogenAssociated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease
Creators - without role: Maria Sabater-Lleal - Karolinska Institutet
Jie Huang - Framingham Heart Study
Daniel Chasman - Brigham and Women's Hospital
Silvia Naitza - CNR, Ist Ric Genet & Biomed, Cagliari, Italy
Abbas Dehghan - Erasmus MC
Andrew D. Johnson - Framingham Heart Study
Alexander Teumer - University of Greifswald
Alex P. Reiner
Lasse Folkersen
Saonli Basu - Florence
Alicja R. Rudnicka - University of London
Stella Trompet - Leiden University
Anders Malarstig - Karolinska Institutet
Jens Baumert - Helmholtz Zentrum München
Joshua C. Bis - University of Washington
Xiuqing Guo - Biomed Research Institute
Jouke J. Hottenga - University of Amsterdam
So-Youn Shin - Wellcome Sanger Institute
Lorna M. Lopez - University of Edinburgh
Jari Lahti - University of Helsinki
Toshiko Tanaka - NIA, Clin Res Branch, Baltimore, MD 21224 USA
Lisa R. Yanek - Johns Hopkins University
Tiphaine Oudot-Mellakh
James F. Wilson - University of Edinburgh
Pau Navarro - College Station Medical Center
Jennifer E. Huffman - College Station Medical Center
Tatijana Zemunik - University of Split
Susan Redline - Harvard University
Reena Mehra - Case Western Reserve University
Drazen Pulanic - College Station Medical Center
Igor Rudan - University of Edinburgh
Alan F. Wright - College Station Medical Center
Ivana Kolcic - University of Split
Ozren Polasek - University of Split
Sarah H. Wild - University of Edinburgh
Harry Campbell - University of Edinburgh
J. David Curb - University of Hawaii System
Robert Wallace - University of Iowa
Simin Liu - Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA 90024 USA
Charles B. Eaton - Brown University
Diane M. Becker - Johns Hopkins University
Lewis C. Becker - Johns Hopkins University
Stefania Bandinelli
Katri Raikkonen - University of Helsinki
Elisabeth Widen - University of Helsinki
Aarno Palotie
Myriam Fornage - Supreme Council Of Health
David Green - Northwestern Univ, Div Hematol Oncol, Feinberg Sch Med, Chicago, IL 60611 USA
Myron Gross - University of Minnesota
Gail Davies - University of Edinburgh
Sarah E. Harris - University of Edinburgh
David C. Liewald - University of Edinburgh
John M. Starr - University of Edinburgh
Frances M. K. Williams - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Peter J. Grant - University of Leeds
Timothy D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Rona J. Strawbridge - Karolinska Institutet
Angela Silveira - Karolinska Institutet
Bengt Sennblad - Karolinska Institutet
Fernando Rivadeneira - Erasmus MC
Andre G. Uitterlinden - Erasmus MC
Oscar H. Franco - Erasmus MC
Albert Hofman - Karolinska Institutet
Jenny van Dongen - University of Amsterdam
Gonneke Willemsen - University of Amsterdam
Dorret I. Boomsma - University of Amsterdam
Jie Yao - College Station Medical Center
Nancy Swords Jenny - University of Vermont
Talin Haritunians - College Station Medical Center
Barbara McKnight - University of Washington
Thomas Lumley - University of Washington
Kent D. Taylor - NIA, Intramural Res Program, Baltimore, MD 21224 USA
Jerome I. Rotter - Biomed Research Institute
Bruce M. Psaty - University of Washington
Annette Peters - Helmholtz Zentrum München
Christian Gieger - Helmholtz Zentrum München
Thomas Illig - Helmholtz Zentrum München
Anne Grotevendt
Georg Homuth - University of Greifswald
Henry Voelzke - University of Greifswald
Thomas Kocher - College Station Medical Center
Anuj Goel
Maria Grazia Franzosi - Mylan
Udo Seedorf - University of Münster
Robert Clarke - University of Oxford
Maristella Steri - CNR, Ist Ric Genet & Biomed, Cagliari, Italy
Kirill V. Tarasov
Serena Sanna
David Schlessinger
David J. Stott - University of Glasgow
Naveed Sattar
Brendan M. Buckley - Natl Univ Ireland Univ Coll Cork, Dept Pharmacol & Therapeut, Cork, Ireland
Ann Rumley - University of Washington
Gordon D. Lowe - University of Glasgow
Wendy L. McArdle - University of Bristol
Ming-Huei Chen - Boston University
Geoffrey H. Tofler - University of Sydney
Jaejoon Song - University of Minnesota
Eric Boerwinkle - Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA
Aaron R. Folsom - University of Minnesota
Lynda M. Rose - Brigham and Women's Hospital
Anders Franco-Cereceda - Karolinska Institutet
Martina Teichert - Erasmus MC
M. Arfan Ikram - Erasmus MC
Thomas H. Mosley - University of Mississippi
Steve Bevan
Martin Dichgans - Univ Munich, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany
Peter M. Rothwell
Cathie L. M. Sudlow - University of Edinburgh
Jemma C. Hopewell - University of Oxford
John C. Chambers - University of London
Danish Saleheen
Jaspal S. Kooner - University of London
John Danesh - University of Cambridge
Christopher P. Nelson - University of Leicester
Jeanette Erdmann - University of Lübeck
Muredach P. Reilly - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
Sekar Kathiresan - Cardiovasc Res Ctr, Boston, MA USA
Heribert Schunkert - University of Lübeck
Pierre-Emmanuel Morange - Aix-Marseille University
Luigi Ferrucci - Karolinska Institutet
Johan G. Eriksson - Natl Inst Hlth & Welf, Helsinki, Finland
David Jacobs
Ian J. Deary - University of Edinburgh
Nicole Soranzo
Jacqueline C. M. Witteman - Erasmus MC
Eco J. C. de Geus - University of Amsterdam
Russell P. Tracy - University of Vermont
Caroline Hayward - College Station Medical Center
Wolfgang Koenig - University of Ulm
Francesco Cucca - CNR, Ist Ric Genet & Biomed, Cagliari, Italy
J. Wouter Jukema - Leiden University
Per Eriksson - Karolinska Institutet
Sudha Seshadri
Hugh S. Markus - University of London
Hugh Watkins - College Station Medical Center
Nilesh J. Samani - University of Leicester
Henri Wallaschofski
Nicholas L. Smith - University of Washington
David Tregouet - Inserm
Paul M. Ridker
Weihong Tang - University of Minnesota
David P. Strachan - University of London
Anders Hamsten
Christopher J. O'Donnell - Framingham Heart Study
VTE Consortium
Panos Deloukas - King Abdulaziz University
Publication Details: Circulation (New York, N.Y.), Vol.128(12), pp.1310-1324
Publisher: Lippincott Williams & Wilkins
Number of pages: 15
Grant note: Netherlands Organization for Health Research and Development (ZonMw); Netherlands Organization for Health Research and Development Italian Ministry of University and Research; Ministry of Education, Universities and Research (MIUR) German Federal Ministry of Education, Science, Research and Technology McNeil Pharma Netherlands Organization for Scientific Research; Netherlands Organization for Scientific Research (NWO) CA047988 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 03IS2061A / Ministry of Cultural Affairs of the Federal State of Mecklenburg, West Pomerania MOP-82810; MOP172605; MOP77682 / CIHR; Canadian Institutes of Health Research (CIHR) 2009B102; NHS 92345 / Netherlands Heart Foundation MC_UU_12013/1; G0700704; MR/L003120/1; MC_PC_U127592696; MC_U127592696; MR/K026992/1; G0000934; MC_U137686857 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) GlaxoSmithKline through an Alternate Drug Discovery Initiative Research Alliance Award U01-HG-004729; U01-HG-004446; U01-HG-004424 / National Human Genome Research Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) 108-1080315-0302 / Republic of Croatia Ministry of Science, Education and Sports; Ministry of Science, Education and Sports, Republic of Croatia Sanofi-Aventis 050-060-810 / NGI/NWO; Netherlands Organization for Scientific Research (NWO) NF-SI-0512-10165 / National Institute for Health Research; National Institutes of Health Research (NIHR) 175.010.2005.011; 911-03-012 / Netherlands Organisation of Scientific Research NWO Investments; Netherlands Organization for Scientific Research (NWO) LBC1921 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Erasmus University Rotterdam Pfizer LBC1936 / Research Into Ageing German National Genome Research Network Institut National de la Sante et de la Recherche Medicale; Institut National de la Sante et de la Recherche Medicale (Inserm) NGFN-2 / German Federal Ministry of Education and Research (BMBF) in the context of the German National Genome Research Network; Federal Ministry of Education & Research (BMBF) 918-76-619 / NWO (Vici); Netherlands Organization for Scientific Research (NWO) Netherlands Heart Foundation French Ministry of Research; Ministry of Research, France Magnus Bergvall Foundation National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) MSD Sharp Dohme Roche; Roche Holding Cariverona Foundation, Verona; Fondazione Cariverona BHF Center of Research Excellence, Oxford Wellcome Trust National Institutes of Health (NIH), NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Cardiovascular Institute of the University of Pennsylvania NA6001 / HSFO R01 AG033193; NS017950 / National Institute for Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Berlin Chemie Medical Research Council (UK); UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Reynolds Foundation Sanofi/Aventis; Sanofi-Aventis National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) LSHG-CT-2006-018947 / European Commission; European Commission Joint Research Centre Philips Medical Systems US NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA N02-HL-6-4278 / Affymetrix, Inc R01 HL087676 / NHLBI's STAMPEED genomics research program 014-93-015; RIDE2 / Research Institute for Diseases in the Elderly Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) BHF Center of Research Excellence, Oxford, UK Karolinska Institutet Amgen CZG/4/306 / Scottish Executive Chief Scientist Office, Health Services Research Committee Ministry of Health Welfare and Sports MAIFOR Swedish Heart-Lung Foundation Wellcome Trust075491/Z/04 UK National Blood Service controls Research Institute for Diseases in the Elderly Research Institute for Diseases in the Elderly (RIDE) Boots Healthcare Foundation for Strategic Research Dade Behring/Siemens Engineering and Physical Sciences Research Council (EPSRC); UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC) Program Hospitalier de la Recherche Clinique 175.010.2005.011; 911.03.012 / Netherlands Organization for Scientific Research (NWO) 01KU0908A / BMBF/ANR; Agence Nationale de la Recherche (ANR) Ministry of Cultural Affairs BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) BB/F019394/1 / Biotechnology and Biological Sciences Research Council (BBSRC); UK Research & Innovation (UKRI) Help the Aged/Research Into Ageing (Disconnected Mind) Johannes-Gutenberg University of Mainz NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Social Ministry of the Federal State of Mecklenburg, West Pomerania Swedish Heart & Lung Foundation; Swedish Heart-Lung Foundation G0000934 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Munich Center of Health Sciences (MC Health) as part of LMUinnovativ ETM/55; CZB/4/710 / Chief Scientist Office RG/08/014/24067; PG/09/022/26739 / British Heart Foundation UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Netherlands Organisation for Scientific Research (NWO); Netherlands Organization for Scientific Research (NWO) Fondation pour la Recherche Medicale Netherlands Organization for Scientific Research (NWO) Federal State of Mecklenburg, West Pomerania Washington Hospital Center 11966 / CFI; Canada Foundation for Innovation MedStar Research Institute La Region Ile de France; Region Ile-de-France Boston Medical Center HEALTH-F2-2009-223004 / European Union's 7th Framework Program; Marie Curie Actions Stockholm County Council State of Bavaria K24 DK080140; DK063491 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Economic and Social Research Council (ESRC); UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) Heart and Stroke Foundation of Ontario; Heart & Stroke Foundation of Ontario 01ZZ9603; 01ZZ0103; 01ZZ0403; 03ZIK012 / Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) Veneto Region; Regione Veneto Fondation Leducq; Leducq Foundation European Commission; European Commission Joint Research Centre LSHM-CT-2006-037593; LSHM-CT-2004-503485; HEALTH-F2-2008-201668 / EU; European Commission Medical Research Council (MRC), as part of the cross-council Lifelong Health and Wellbeing Initiative; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Erasmus Medical Center and Erasmus University Rotterdam N01-HC-25195 / National Heart, Lung, and Blood Institute's (NHLBI's) King Pharmaceuticals Glaxo-Smith-Kline; GlaxoSmithKline Boehringer Ingelheim LSHM-CT-2007-037273 / European Community; European Commission German Migraine & Headache Society PIEF-GA-2009-252361 / European Union; European Commission; Spanish Government HHSN268201200036C; HL080295; HL087652; HL105756; R01-HL085251; HL087647; N01-HC-55015; N01-HC-55016; N01-HC-55018; N01-HC-55019; N01-HC-55020; N01-HC-85085; N01-HC-85086; N01-HC-35129; N01 HC-15103; N01 HC-55222; N01-HC-75150; N01-HC-45133 / N.H.L.B.I; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Municipality of Rotterdam Althingi (the Icelandic Parliament) BB/F019394/1 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Macular Disease Society 068545/Z/02 / Wellcome Trust h1231 / Leibniz Supercomputing Center of the Bavarian Academy of Sciences and Humanities (HLRB) European Commission (DG XII); European Commission; European Commission Joint Research Centre HL043851; HL080467; N01-HC-95095; N01-HC-48047; N01-HC-48048; N01-HC-48049; N01-HC-48050; N01-HC-45134; N01-HC-05187; N01-HC-45205; N01-HC-45204; N01-HC-85239; N01-HC-85079; N01-HC-85080; N01-HC-85081; N01-HC-85082; N01-HC-85083; N01-HC-85084 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Zoll LifeCor Institute of Epidemiology and Social Medicine, University of Muenster Medtronic Donald W. Reynolds Foundation Medical Research Council UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) UL1TR000124 / National Center of Advancing Translational Technologies CTSI Fondation de France Canadian Institutes for Health Research; Canadian Institutes of Health Research (CIHR) Knut and Alice Wallenberg Foundation; Knut & Alice Wallenberg Foundation Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) AstraZeneca Torsten and Ragnar Soderberg Foundation NHLBI R01HL089650-02; N01-AG-12100; P01 HL098055; P01HL076491-06; R01DK080732; P01HL087018; 1RO1HL103931-01 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA British Heart Foundation (BHF); British Heart Foundation BHF; British Heart Foundation MC_U137686857; G0000934; MC_PC_U127592696; MC_UU_12013/1; G0700704; MR/L003120/1; MC_U127592696 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) University of Pennsylvania School of Medicine Ministry of Education, Culture and Science; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) 05060810 / Netherlands Consortium of Healthy Aging (NGI) BB/F019394/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Siemens Healthcare, Erlangen, Germany; Siemens AG T.F.C. Frost charity Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine vici, 918-76-619; veni, 916.12.154 / NWO; Netherlands Organization for Scientific Research (NWO) Cancer Research UK EUR Fellowship GlaxoSmithKline Government of Rheinland-Pfalz Stockholm County Council (ALF); Stockholm County Council National Institute on Aging (NIA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Helmholtz Zentrum Munchen-National Research Center for Environmental Health NO1-AG-1-2109; AG-023629; AG-15928; AG-20098; AG-027058 / NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) Erasmus Medical Center 050-060-810 / Netherlands Genomics Initiative (NGI)/Netherlands Consortium for Healthy Aging (NCHA)
Identifiers: 9938819908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article