Abstract
Strategic design of gadofullerene derivatives is critical to integrate multifunctionality into one entity. Herein, an easy method was developed to fabricate a new type of magnetic resonance imaging/fluorescent integrative molecular imaging probe based on Gd@C-82. The functionalized gadofulleride Gd@C82O similar to 14(OH)(similar to 14)(NH2)(similar to 6) not only exhibits an order of magnitude larger relaxivity (47.0 +/- 0.8 mM(-1) s(-1) at 0.5 T) than commercially used gadopentetic acid (4.5 +/- 0.1 mM(-1) s(-1)) under the same condition and multi-wavelength emission features derived from the multi-wavelength excitation for dual-modality diagnosis, but also highly efficient scavenging capability toward hydroxyl radicals. (C) 2013 Elsevier Ltd. All rights reserved.