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N-Acyl glycinates as acyl donors in serine protease-catalyzed kinetic resolution of amines. Improvement of selectivity and reaction rate
Journal article   Peer reviewed

N-Acyl glycinates as acyl donors in serine protease-catalyzed kinetic resolution of amines. Improvement of selectivity and reaction rate

Malek Nechab, Lahssen El Blidi, Nicolas Vanthuyne, Stephane Gastaldi, Michele P. Bertrand and Gerard Gil
Organic & biomolecular chemistry, Vol.6(21), pp.3917-3920
01/01/2008
DOI: https://doi.org/10.1039/b812089g
PMID: 18931797

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Enzymatic kinetic resolution of aliphatic and benzylic amines leading to (S)-amides was achieved by using alkaline protease as the catalyst and N-octanoyl glycine trifluoroethyl ester as the acyl donor; enantioselectivity ranged between 4 to 244, while reaction times were dramatically shortened and ranged between 15 min to 6 h.

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