Abstract
Mesoporous silica materials modified amines-amides- and glycinate N-halamine were prepared in three different ways. The 3-chloropropyl functionalized mesoporous silica (MS-Cl) was treated with N-ethylamine or N-butylamine, followed by chlorination with sodium hypochlorite solution, to produce the amines N-halamine functionalized mesoporous silica (MS-NCl-E and MS-NCl-B). The 3-glycinatepropyl functionalized mesoporous silica (MS-G) was treated with the appropriate N-ethylamine or N-butylamine, followed by chlorination with sodium hypochlorite solution, to generate the amides N-halamine functionalized mesoporous silica (MS-G-E-Cl and MS-G-B-Cl). When chlorinated with sodium hypochlorite solution, the N-halamine mesoporous materials for water disinfection demonstrated a potent antibacterial activity and were instantly rechargeable. The texture features of these materials were explored by N2 adsorption/desorption isotherms utilizing (BET), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and elemental analysis, among other techniques, to evaluate their structure. Quantum and chemical results of amines N-halamine (MS1NCl-E, MS1NCl-B, MS2NCl-B), and glycinates N-halamine (MS-G-Cl, MS-NCl-B, MS-NCl-E) showed higher effective for sterilization of E. Coli in water samples than that of amides N-halamine (MS-G-B-Cl, MS-G-E-Cl).
Schematic description of N-halamines functionalized mesoporous silica and their antibacterial activity. [Display omitted]
•Several N-halamine compounds including amines, glycinates and amides immobilized mesoporous silica are prepared.•The order of antibacterial activity for E. Coli disinfection form water is glycinates > amides.•The computed results showed that the investigated N-halamines can be classified as very strong electrophiles.•These materials are stable easily rechargeable and reproducible.