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N-Heterocyclic-Carbene-Catalysed Diastereoselective Vinylogous Mukaiyama/Michael Reaction of 2-(Trimethylsilyloxy)furan and Enones
Journal article   Peer reviewed

N-Heterocyclic-Carbene-Catalysed Diastereoselective Vinylogous Mukaiyama/Michael Reaction of 2-(Trimethylsilyloxy)furan and Enones

Ying Wang, Guang-Fen Du, Fen Xing, Kuo-Wei Huang, Bin Dai and Lin He
Asian journal of organic chemistry, Vol.4(12), pp.1362-1365
01/12/2015
DOI: https://doi.org/10.1002/ajoc.201500348

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
N-heterocyclic carbenes have been utilised as highly efficient nucleophilic organocatalysts to mediate vinylogous Mukaiyama/Michael reactions of 2-(trimethylsilyloxy)furan with enones to afford gamma-substituted butenolides in 44-99% yield with 3: 1-32: 1 diastereoselectivity.

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