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N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2
Journal article   Open access  Peer reviewed

N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

Orlando Santoro, Faima Lazreg, Yury Minenkov, Luigi Cavallo and Catherine S. J. Cazin
Dalton transactions : an international journal of inorganic chemistry, Vol.44(41), pp.18138-18144
07/11/2015
DOI: https://doi.org/10.1039/c5dt03506f
PMID: 26420462

Abstract

Chemistry Chemistry, Inorganic & Nuclear Physical Sciences Science & Technology
The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.
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https://doi.org/10.1039/c5dt03506fView
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