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NEW APPLICATION OF SWERN OXIDATION: PREPARATION OF 2-PYRAZOLINES WITH "ACTIVATED" DMSO
Journal article

NEW APPLICATION OF SWERN OXIDATION: PREPARATION OF 2-PYRAZOLINES WITH "ACTIVATED" DMSO

Naoufel Ben Hamadi, W. Abd El-Fattah and Ahlem Guesmi
Heterocyclic letters, Vol.11(1), pp.25-29
01/11/2021

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
1,3-Dipolar cycloaddition of 2-diazopropane 2 to conjugateddi-substituted alkenes1 is taking place regiospecifically to give five membered heterocyclic ring 3. The oxidation of 2-pyrazolines 3a,b with dimethylsulfoxide and oxalyl chloride under Swern conditions led to a pyrazolenines 5a,b.

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