Abstract
A super-fast (within 4 min only) HPLC method is described for the analyses of aspirin and atorvastatin simultaneously in single dosage formulation. The mobile phase used was water (pH 2.0, adjusted by o-phosphoric acid)-acetonitrile (50:50, v/v) at 1.0 mL/min flow rate with 210 nm detection. The column used was new generation Halo C
18
(100 × 46 mm; shell particles; 2.7 µm). The capacity factors of aspirin and atorvastatin were 1.20 and 2.01, while the separation and resolution factors were 1.68 and 5.63, respectively. The values of LOD and LOQ for aspirin were 0.10 and 0.50 µg/mL, while these values for atorvastatin were 0.50 and 2.5 µg/mL, respectively. The linearity was observed in the ranges of 0.1 to 5.0 mg/mL for both drugs. The reported method can be used for the quality control of aspirin and atorvastatin in pharmaceutical preparations with good economy. Additionally, this method can also be used for the analyses of aspirin and atorvastatin drugs in biological and environmental samples.