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NF-κB Activation in Esophageal Adenocarcinoma: Relationship to Barrett's Metaplasia, Survival, and Response to Neoadjuvant Chemoradiotherapy
Journal article   Peer reviewed

NF-κB Activation in Esophageal Adenocarcinoma: Relationship to Barrett's Metaplasia, Survival, and Response to Neoadjuvant Chemoradiotherapy

Mohamed M. M. Abdel-Latif, James O'Riordan, Henry J. Windle, Eleanor Carton, Nagunivan Ravi, Dermot Kelleher and John V. Reynolds
Annals of surgery, Vol.239(4), pp.491-500
01/04/2004
DOI: https://doi.org/10.1097/01.sla.0000118751.95179.c6
PMCID: PMC1356254
PMID: 15024310

Abstract

Original
Esophageal adenocarcinoma tumor tissues contain high levels of activated nuclear factor kappa-B (NF-κB), and the absence of NF-κB in esophageal cancer correlates with the early stage of the disease and with responsiveness to neoadjuvant therapy. Exposure of esophageal cancer cells to deoxycholic acid or low pH induced NF-κB expression.

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