Abstract
NS3 serine protease is considered as one of the most important non-structure proteins for hepatitis C virus (HCV) replication. The significance of NS3 protease function is the conversion of polypeptides to functional proteins to produce new mature HCV. Knowing that the currently available treatment is expensive and effective in only 50-60% of treated patients. It is thus crucially important to exert maximum effort in the design of new formulations aiming to achieve better treatment performance.