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NUCLEOPHILIC ADDITION REACTIONS ON 3-CARBETHOXY- 5,7-DIMETHOXYCOUMARIN
Journal article   Peer reviewed

NUCLEOPHILIC ADDITION REACTIONS ON 3-CARBETHOXY- 5,7-DIMETHOXYCOUMARIN

M. A. Hassan, S. A. Shiba, N. S. Harb, M. K. Abou-El-Regal and S. A. El-Metwally
Synthetic communications, Vol.32(5), pp.679-688
01/01/2002

Abstract

3-Carbethoxy-5,7-dimethoxycoumarin (2) underwent Michael addition and addition-cyclization of some active methylene compounds under different reaction conditions to give the adducts (3-7). Addition of phenylmagnesium bromide onto (2) yielded the tertiary alcohol (8). Addition of ammonia derivatives on (2) afforded the 3-carboxamides (9a-c) and azine (10). Furthermore, alcoholysis and hydrolysis yielded the coumarins (11a-c).

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