Abstract
A left ventricular assist device (LVAD) is a surgically implanted mechanical pump being used for patients with end-stage heart failure (HF). One of the significant clinical challenges in using LVADs is its remarkable changes in hemodynamic parameters during a change in body position from supine to standing. In standing position, vasodilatation of veins occurs in the legs, which decreases left ventricular end-diastolic pressure, and, in turn, the preload to the LVAD. In this research, a numerical investigation is carried out to evaluate the effect of LVAD in cardiac hemodynamic parameters such as cardiac output (CO) and stroke work (SW) under preload, normal, and afterload conditions. A Proportional–integral–derivative (PID) controller associated with an LVAD pump model and cardiovascular system (CVS) model is developed to study the cardiac hemodynamic and its performance during HF condition by changing system parameters in one cardiac cycle. The performance of the proposed model is then evaluated using a pump cannulae model, real-time status detection of the aortic valve (av), and left ventricular stroke volume. The model parameters associated with HF, including contractility of the left and right ventricle ([Formula: see text] & [Formula: see text]), systemic peripheral resistance ([Formula: see text]) and total blood volume ([Formula: see text]) were set 0.71[Formula: see text]mmHg.s.mL[Formula: see text], 0.53[Formula: see text]mmHg.s.mL[Formula: see text], 1.11[Formula: see text]mmHg.s.mL[Formula: see text] and 5800[Formula: see text]mL, respectively, to allow simulation of HF conditions. The findings of this study show that the CO is increasing linearly with end-diastolic left ventricular volume (LV
EDV
) and end-diastolic right ventricular volume (RV
EDV
). However, other vital parameters behavior has a nonlinear relation to CO. Results of this study prove that the LVAD model is more sensitive to preload than afterload condition under different hemodynamical conditions.