Abstract
Two new divalent copper (C1) and zinc (C2) chelates having the formulae [M(PIMC)2] (where M = Cu(II), Zn(II) and PIMC = Ligand [(E)‐3‐(((3‐hydroxypyridin‐2‐yl)imino)methyl)‐4H‐chromen‐4‐one] were obtained and characterized by several techniques. Structures and geometries of the synthesized complexes were judged based on the results of alternative analytical and spectral tools supporting the proposed formulae. IR spectral data confirmed the coordination of the ligands to the copper and zinc centers as monobasic tridentate in the enol form. Thermal analysis, UV‐Vis spectra and magnetic moment confirmed the geometry around the copper center to be tetrahedral, square pyramidal and octahedral. Study of the binding ability of the synthesized compounds with Circulating tumor DNA (CT‐DNA) bas been evaluated applying UV‐Vis spectral titration and viscosity measurements. The copper and zinc oxides were achieved from the copper and zinc nano‐particles structures Schiff base complexes as the raw material after calcination for 5 hr at 600°C. On the other hand, synthesized of C1 and C2 NPs were used as suitable precursors to the preparation of CuO and ZnO NPs. Finally, the synthesized of the two complexes exhibited enhanced activity against the tested bacterial (Staphylococcus aureus and Escherichia Coli) and fungal strains (Candida albicans and Aspergillus fumigatus) as compared to HPIMC. Among all these synthesized compounds, C1 exhibits good cleaving ability compared to other newly synthesized C2.
Two novel nano‐sized complexes (C1 and C2) were synthesized and characterized by spectral, thermal, and density functional theory studies and their geometry was confirmed. We also investigated the in vitro antimicrobial activity of the complexes. Furthermore, an anticancer study was performed to understand the nature of binding of the synthesized compounds to protein and DNA.