Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized
by memory impairment, dementia, and oxidative stress in elderly people. Currently, only
a few drugs are available in the market with various adverse effects. Therefore, to develop
new drugs with protective action against the disease, research is turning to the identification of
plant products as a remedy. Natural compounds with anti-inflammatory activity could be good
candidates for developing effective therapeutic strategies. Phytochemicals, including Curcumin,
Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol,
were reported molecules for the treatment of AD. Several alkaloids, such as galantamine,
oridonin, glaucocalyxin B, tetrandrine, berberine and anatabine, have been shown
anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural
products from plants represent interesting candidates for the treatment of AD. This review
highlights the potential of specific compounds from natural products along with their synthetic
derivatives to counteract AD in the CNS.