Abstract
Rosacea is a chronic, persistent, inflammatory skin disease of the central face and eyes, caused by immune dysfunction and neurovascular dysregulation, that presents with recurrent flushing, erythema, telangiectasia, papules, or pustules. Rosacea affects quality of life and social and mental health. Recent research has linked rosacea to autoimmune, gastrointestinal, neurological, and psychiatric diseases and cancer risks. This review discusses the rosacea subtype-directed approach management, new topical and systemic formulations, and therapy combinations depending on new phenotype classification.