Abstract
A new series of pyrido[2,3-d]pyrimidones incorporated pyrazoles and fused triazoles are synthesized and tested in vitro for cytotoxic effect against cancer cell lines: HePG-2, HCT-116, MCF-7, PC-3, and A-549. Their inhibition of protein kinase is assessed. The highest growth inhibitory (IC50 0.3 mu M) effect is determined for one of compounds as compared with doxorubicin (IC50 0.6 mu M). A modeling study is performed for approaching the compounds mode of binding and their similarity with the positive control drugs.