Abstract
The purpose of this work was to prepare Schiff base ligands containing quinoline moiety and using them for preparing Cu(
) and Zn(
) complexes. Four bidentate Schiff base ligands (SL
–SL
) with quinoline hydrazine scaffold and a series of mononuclear Cu(
) and Zn(
) complexes were successfully prepared and characterized. The
antibacterial and antifungal potential experimentation revealed that the ligands exhibited moderate antibacterial activity against the Gram-positive bacterial types and were inactive against the Gram-negative bacteria and the fungus strains. The metal complexes showed some enhancement in the activity against the Gram-positive bacterial strains and were inactive against the Gram-negative bacteria and the fungus strains similar to the parent ligands. The complex [Cu(SL
] was the most toxic compound against both Gram-positive
and
bacteria. The
physicochemical investigation revealed that the ligand SL
showed highest
absorption (82.61%) and the two complexes [Cu(SL
] and [Zn(SL
] showed highest
absorption with 56.23% for both compounds. The
pharmacokinetics predictions showed that the ligands have high gastrointestinal (GI) absorption and the complexes showed low GI absorption. The ligands showed a good bioavailability score of 0.55 where the complexes showed moderate to poor bioavailability.