Abstract
New validated carbon paste and chemically Modified carbon nanotubes (MCNTs) sensors for determination of pantoprazole sodium (PA) were developed.: The developed method was based On the fabrication of two types of, sensors carbon paste (I), and modified carbon nanotubes (11). The employed sensors Were fabricated using electroactive materials pantoprazole-phosphomolybdate (PA-PM). The performance characteristics of the proposed sensors were carefully studied. The Sensors exhibited nearly Nernstain responses (55 +/- 0.3 And 57,3 0:8 ITN decade(-1)) for pantoprazole-phosphomolybdate carbon paste and, modified-carbon nanotubes sensors at 25 C over drug concentration ranges (1 x 10(-6)-1 x 10(-3) and 1 x 10(-7)-1 x 10(-2) mol L-1) with lower detection limits of (9.1 x 10(-8) and 9.8 x 10(-9) mol L-1) for the previously mentioned sensors, respectively. The fabricated sensors were safely used at pH 4-8 and displayed good isothermal Coefficients 0.00105 and 0:00042 V degrees C-1 for pantoprazole-phosphomolybdate carbon paste and modified carbon nanotubes sensors, respectively. The influence of common and possible interfering :species, pharmaceutical additives and some related pharmacological action drugs was investigated using both separate solution and Mixed solution Methods. No interference was found. The stability indicating using forced degradation of pantoprazole Odium was also studied. The results Of the proposed method Were validated and Statistically analyzed by recoveries studies and compared with those obtained from previously reported methods. The proposed method was successfully applied for quantification of the investigated drug in pure form, its dosage forms and biological fluids.