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New cytotoxic constituents from the Red Sea soft coral Nephthea sp
Journal article   Peer reviewed

New cytotoxic constituents from the Red Sea soft coral Nephthea sp

Mohamed-Elamir F. Hegazy, Amira M. Gamal-Eldeen, Tarik A. Mohamed, Montaser A. Alhammady, Abuzeid A. Hassanien, Mohamed A. Shreadah, Ibrahim I. Abdelgawad, Eman M. Elkady and Paul W. Pare
Natural product research, Vol.30(11), pp.1266-1272
02/06/2016
DOI: https://doi.org/10.1080/14786419.2015.1055266
PMID: 26165402

Abstract

Chemistry Chemistry, Applied Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Physical Sciences Science & Technology
Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2-9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.

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