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New cytotoxic cyclic peroxide acids from Plakortis sp marine sponge
Journal article   Open access  Peer reviewed

New cytotoxic cyclic peroxide acids from Plakortis sp marine sponge

Thomas R. Hoye, Walied M. Alarif, Salim S. Basaif, Mohamed Abo-Elkarm, Mark T. Hamann, Amir E. Wahba and Seif-Eldin N. Ayyad
ARKIVOC free online journal of organic chemistry, Vol.2015(5), pp.164-175
01/01/2015
DOI: https://doi.org/10.3998/ark.5550190.p008.948
PMCID: PMC4732738
PMID: 26835518

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.
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https://doi.org/10.3998/ark.5550190.p008.948View
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