Abstract
Seven alkaloids, of indole nucleus, were isolated from Rhazya stricta (Apocynaceae). Two of which are new, epi-rhazyaminine and 20-epi-sitsirikine. All isolated compounds were tested against three cancer cell lines; colon cancer (HCT-116), prostate cancer (PC-3), human hepatocellular liver carcinoma (HepG2) and normal adult African green monkey kidney (VERO). [Display omitted]
Seven alkaloids of indole nucleus were isolated from Rhazya stricta (Apocynaceae). Two of which are new epi-rhazyaminine (1) and 20-epi-sitsirikine (2), while the rest are known; eburenine (3), strictamine (4), (16 R)-E-isositsirikine (5), antirhine (6), and strictanol (7). The chemical structures of the isolated compounds were elucidated by interpretation of the obtained spectral data 1D (1H, 13C and DEPT) and 2D (COSY, HSQC, HMBC and NOESY) NMR, UV, IR and MS. Compounds 1-7 were tested against three cancer cell lines; human colorectal carcinoma (HCT-116), prostate cancer (PC-3), human hepatocellular liver carcinoma (HepG2) and normal adult African green monkey kidney (VERO).
•<Seven alkaloids, of indole nucleus, were isolated from Rhazya stricta (Apocynaceae)>, <Two new indole-type alkaloids epi-rhazyaminine and 20-epi-sitsirikine were obtained>, <The chemical structures of the isolated compounds were elucidated by interpretation spectral data of 1D and 2D NMRR, UV, IR and MS>, <Compounds 1-7 were tested against three cancer cell lines (HCT-116, PC-3 and HepG2) and a normal cell line (VERO)> .