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New cytotoxic xenia diterpenoids from the Formosan soft coral Xenia umbellata
Journal article   Peer reviewed

New cytotoxic xenia diterpenoids from the Formosan soft coral Xenia umbellata

Chang-Yih Duh, Ali Ali H El-Gamal, Chin-Ying Chiang, Chih-Ju Chu, Shang-Kwei Wang and Chang-Feng Dai
Journal of natural products (Washington, D.C.), Vol.65(12), pp.1882-1885
01/12/2002
DOI: https://doi.org/10.1021/np020268z
PMID: 12502332

Abstract

Animals Anthozoa - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Chromatography, Thin Layer Colonic Neoplasms Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Leukemia P388 Lung Neoplasms Mice Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Stereoisomerism Taiwan Tumor Cells, Cultured - drug effects
Seven new cytotoxic xenicane-type diterpenoids, 9-deoxyxeniloide-E (1), 9-deoxy-7,8-epoxyxeniloide-E (2), xeniolide-G (3), 9-deoxyxenialactol-C (4), xenibecin (5), xeniolide-H (6), and xenitacin (7), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia umbellata. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

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