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New dirhodium complex with activity towards colorectal cancer
Journal article   Peer reviewed

New dirhodium complex with activity towards colorectal cancer

Raquel F. M. Frade, Nuno R. Candeias, Catarina M. M. Duarte, Vania Andre, M. Teresa Duarte, Pedro M. P. Gois and Carlos A. M. Afonso
Bioorganic & medicinal chemistry letters, Vol.20(11), pp.3413-3415
01/06/2010
DOI: https://doi.org/10.1016/j.bmcl.2010.04.002
PMID: 20434912

Abstract

Chemistry Chemistry, Medicinal Chemistry, Organic Life Sciences & Biomedicine Pharmacology & Pharmacy Physical Sciences Science & Technology
A novel dirhodium complex (Rh-2(L-PheAla)(2)(OAc)(2) is reported with strong activity towards human colon adenocarcinoma cells. Its effect was not accompanied by generation of reactive oxygen species (ROS) neither by activation of caspase-3. (C) 2010 Elsevier Ltd. All rights reserved.

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