New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Josee Dupuis; Claudia Langenberg; Inga Prokopenko; Richa Saxena; Nicole Soranzo; Anne U. Jackson; Eleanor Wheeler; Nicole L. Glazer; Nabila Bouatia-Naji; Anna L. Gloyn; Cecilia M. Lindgren; Reedik Magi; Andrew P. Morris; Joshua Randall; Toby Johnson; Paul Elliott; Denis Rybin; Gudmar Thorleifsson; Valgerdur Steinthorsdottir; Peter Henneman; Harald Grallert; Abbas Dehghan; Jouke Jan Hottenga; Christopher S. Franklin; Pau Navarro; Kijoung Song; Anuj Goel; John R. B. Perry; Josephine M. Egan; Taina Lajunen; Niels Grarup; Thomas Sparso; Alex Doney; Benjamin F. Voight; Heather M. Stringham; Man Li; Stavroula Kanoni; Peter Shrader; Christine Cavalcanti-Proenca; Meena Kumari; Lu Qi; Nicholas J. Timpson; Christian Gieger; Carina Zabena; Ghislain Rocheleau; Erik Ingelsson; Ping An; Jeffrey O'Connell; Jian'an Luan; Amanda Elliott; Steven A. McCarroll; Felicity Payne; Rosa Maria Roccasecca; Francois Pattou; Praveen Sethupathy; Kristin Ardlie; Yavuz Ariyurek; Beverley Balkau; Philip Barter; John P. Beilby; Yoav Ben-Shlomo; Rafn Benediktsson; Amanda J. Bennett; Sven Bergmann; Murielle Bochud; Eric Boerwinkle; Amelie Bonnefond; Lori L. Bonnycastle; Knut Borch-Johnsen; Yvonne Boettcher; Eric Brunner; Suzannah J. Bumpstead; Guillaume Charpentier; Yii-Der Ida Chen; Peter Chines; Robert Clarke; Lachlan J. M. Coin; Matthew N. Cooper; Marilyn Cornelis; Gabe Crawford; Laura Crisponi; Ian N. M. Day; Eco J. C. de Geus; Jerome Delplanque; Christian Dina; Michael R. Erdos; Annette C. Fedson; Antje Fischer-Rosinsky; Nita G. Forouhi; Caroline S. Fox; Rune Frants; Maria Grazia Franzosi; Pilar Galan; Mark O. Goodarzi; Juergen Graessler; Christopher J. Groves; Scott Grundy; Rhian Gwilliam; Ulf Gyllensten; Samy Hadjadj; Goeran Hallmans; Naomi Hammond; Xijing Han; Anna-Liisa Hartikainen; Neelam Hassanali; Caroline Hayward; Simon C. Heath; Serge Hercberg; Christian Herder; Andrew A. Hicks; David R. Hillman; Aroon D. Hingorani; Albert Hofman; Jennie Hui; Joe Hung; Bo Isomaa; Paul R. V. Johnson; Torben Jorgensen; Antti Jula; Marika Kaakinen; Jaakko Kaprio; Y. Antero Kesaniemi; Mika Kivimaki; Beatrice Knight; Seppo Koskinen; Peter Kovacs; Kirsten Ohm Kyvik; G. Mark Lathrop; Debbie A. Lawlor; Olivier Le Bacquer; Cecile Lecoeur; Yun Li; Valeriya Lyssenko; Robert Mahley; Massimo Mangino; Alisa K. Manning; Maria Teresa Martinez-Larrad; Jarred B. McAteer; Laura J. McCulloch; Ruth McPherson; Christa Meisinger; David Melzer; David Meyre; Braxton D. Mitchell; Mario A. Morken; Sutapa Mukherjee; Silvia Naitza; Narisu Narisu; Matthew J. Neville; Ben A. Oostra; Marco Orru; Ruth Pakyz; Colin N. A. Palmer; Giuseppe Paolisso; Cristian Pattaro; Daniel Pearson; John F. Peden; Nancy L. Pedersen; Markus Perola; Andreas F. H. Pfeiffer; Irene Pichler; Ozren Polasek; Danielle Posthuma; Simon C. Potter; Anneli Pouta; Michael A. Province; Bruce M. Psaty; Wolfgang Rathmann; Nigel W. Rayner; Kenneth Rice; Samuli Ripatti; Fernando Rivadeneira; Michael Roden; Olov Rolandsson; Annelli Sandbaek; Manjinder Sandhu; Serena Sanna; Avan Aihie Sayer; Paul Scheet; Laura J. Scott; Udo Seedorf; Stephen J. Sharp; Beverley Shields; Gunnar Sigurosson; Eric J. G. Sijbrands; Angela Silveira; Laila Simpson; Andrew Singleton; Nicholas L. Smith; Ulla Sovio; Amy Swift; Holly Syddall; Ann-Christine Syvanen; Toshiko Tanaka; Barbara Thorand; Jean Tichet; Anke Tonjes; Tiinamaija Tuomi; Andre G. Uitterlinden; Ko Willems van Dijk; Mandy van Hoek; Dhiraj Varma; Sophie Visvikis-Siest; Veronique Vitart; Nicole Vogelzangs; Gerard Waeber; Peter J. Wagner; Andrew Walley; G. Bragi Walters; Kim L. Ward; Hugh Watkins; Michael N. Weedon; Sarah H. Wild; Gonneke Willemsen; Jaqueline C. M. Witteman; John W. G. Yarnell; Eleftheria Zeggini; Diana Zelenika; Bjorn Zethelius; Guangju Zhai; Jing Hua Zhao; M. Carola Zillikens; Ingrid B. Borecki; Ruth J. F. Loos; Pierre Meneton; Patrik K. E. Magnusson; David M. Nathan; Gordon H. Williams; Andrew T. Hattersley; Kaisa Silander; Veikko Salomaa; George Davey Smith; Stefan R. Bornstein; Peter Schwarz; Joachim Spranger; Fredrik Karpe; Alan R. Shuldiner; Cyrus Cooper; George V. Dedoussis; Manuel Serrano-Rios; Andrew D. Morris; Lars Lind; Lyle J. Palmer; Frank B. Hu; Paul W. Franks; Shah Ebrahim; Michael Marmot; W. H. Linda Kao; James S. Pankow; Michael J. Sampson; Johanna Kuusisto; Markku Laakso; Torben Hansen; Oluf Pedersen; Peter Paul Pramstaller; H. Erich Wichmann; Thomas Illig; Igor Rudan; Alan F. Wright; Michael Stumvoll; Harry Campbell; James F. Wilson; Richard N. Bergman; Thomas A. Buchanan; Francis S. Collins; Karen L. Mohlke; Jaakko Tuomilehto; Timo T. Valle; David Altshuler; Jerome I. Rotter; David S. Siscovick; Brenda W. J. H. Penninx; Dorret I. Boomsma; Panos Deloukas; Timothy D. Spector; Timothy M. Frayling; Luigi Ferrucci; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson; Cornelia M. van Duijn; Yurii S. Aulchenko; Antonio Cao; Angelo Scuteri; David Schlessinger; Manuela Uda; Aimo Ruokonen; Marjo-Riitta Jarvelin; Dawn M. Waterworth; Peter Vollenweider; Leena Peltonen; Vincent Mooser; Goncalo R. Abecasis; Nicholas J. Wareham; Robert Sladek; Philippe Froguel; Richard M. Watanabe; James B. Meigs; Leif Groop; Michael Boehnke; Mark I. McCarthy; Jose C. Florez; Ines Barroso; DIAGRAM Consortium

doi:10.1038/ng.520

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Journal article

Peer reviewed

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne U. Jackson, Eleanor Wheeler, Nicole L. Glazer, Nabila Bouatia-Naji, Anna L. Gloyn, …

Nature genetics, Vol.42(2), pp.105-U32

01/02/2010

DOI: https://doi.org/10.1038/ng.520

PMCID: PMC3018764

PMID: 20081858

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.

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Title: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Creators - without role: Josee Dupuis - National Heart Lung and Blood Institute
Claudia Langenberg - MRC Epidemiology Unit
Inga Prokopenko - Oxford Centre for Diabetes, Endocrinology and Metabolism
Richa Saxena - Broad Institute
Nicole Soranzo - Wellcome Sanger Institute
Anne U. Jackson - University of Michigan–Ann Arbor
Eleanor Wheeler - Wellcome Sanger Institute
Nicole L. Glazer - University of Washington
Nabila Bouatia-Naji - Pasteur Institute of Lille
Anna L. Gloyn - University of Oxford
Cecilia M. Lindgren - Oxford Centre for Diabetes, Endocrinology and Metabolism
Reedik Magi - Oxford Centre for Diabetes, Endocrinology and Metabolism
Andrew P. Morris - University of Oxford
Joshua Randall - Wellcome Centre for Human Genetics
Toby Johnson - University of Lausanne
Paul Elliott - Imperial College London
Denis Rybin - Boston University
Gudmar Thorleifsson - deCODE Genetics
Valgerdur Steinthorsdottir - deCODE Genetics
Peter Henneman - Leiden University
Harald Grallert - Helmholtz Zentrum München
Abbas Dehghan - College Station Medical Center
Jouke Jan Hottenga - Vrije Universiteit Amsterdam
Christopher S. Franklin - University of Edinburgh
Pau Navarro - MRC Institute of Genetics and Molecular Medicine
Kijoung Song - GlaxoSmithKline
Anuj Goel - Wellcome Centre for Human Genetics
John R. B. Perry - University of Exeter
Josephine M. Egan - National Institute on Aging
Taina Lajunen - University of Oulu
Niels Grarup - Hagedorn Res Inst, Gentofte, Denmark
Thomas Sparso - Hagedorn Res Inst, Gentofte, Denmark
Alex Doney - University of Dundee
Benjamin F. Voight - Broad Institute
Heather M. Stringham - University of Michigan–Ann Arbor
Man Li - Bloomberg
Stavroula Kanoni - Harokopio University of Athens
Peter Shrader - Massachusetts General Hospital
Christine Cavalcanti-Proenca - Pasteur Institute of Lille
Meena Kumari - University College London
Lu Qi - Harvard University
Nicholas J. Timpson - University of Bristol
Christian Gieger - Helmholtz Zentrum München
Carina Zabena - Hospital Clínico San Carlos
Ghislain Rocheleau - McGill University
Erik Ingelsson - Karolinska Institutet
Ping An - Supreme Council Of Health
Jeffrey O'Connell - University of Maryland, Baltimore
Jian'an Luan - MRC Epidemiology Unit
Amanda Elliott - Broad Institute
Steven A. McCarroll - Broad Institute
Felicity Payne - Wellcome Sanger Institute
Rosa Maria Roccasecca - Wellcome Sanger Institute
Francois Pattou - University of Lille Nord de France
Praveen Sethupathy - National Human Genome Research Institute
Kristin Ardlie - Broad Institute
Yavuz Ariyurek - Leiden University Medical Center
Beverley Balkau - University of Paris-Sud
Philip Barter - The Heart Research Institute
John P. Beilby - Queen Elizabeth II Medical Centre
Yoav Ben-Shlomo - University of Bristol
Rafn Benediktsson - Reykjavík University
Amanda J. Bennett - University of Oxford
Sven Bergmann - University of Lausanne
Murielle Bochud - University Hospital of Lausanne
Eric Boerwinkle - The University of Texas Health Science Center at Houston
Amelie Bonnefond - Pasteur Institute of Lille
Lori L. Bonnycastle - National Human Genome Research Institute
Knut Borch-Johnsen - Steno Diabetes Center
Yvonne Boettcher - College Station Medical Center
Eric Brunner - University College London
Suzannah J. Bumpstead - Wellcome Sanger Institute
Guillaume Charpentier - Corbeil Essonnes Hosp, Endocrinol Diabetol Unit, Essonnes, France
Yii-Der Ida Chen - Cedars-Sinai Medical Center
Peter Chines - National Human Genome Research Institute
Robert Clarke - University of Oxford
Lachlan J. M. Coin - University of London
Matthew N. Cooper - University of Western Australia
Marilyn Cornelis - Harvard University
Gabe Crawford - Broad Institute
Laura Crisponi - Institute of Genetic and Biomedical Research
Ian N. M. Day - University of Bristol
Eco J. C. de Geus - Vrije Universiteit Amsterdam
Jerome Delplanque - Pasteur Institute of Lille
Christian Dina - Pasteur Institute of Lille
Michael R. Erdos - National Human Genome Research Institute
Annette C. Fedson - University of Western Australia
Antje Fischer-Rosinsky - Charité - Universitätsmedizin Berlin
Nita G. Forouhi - MRC Epidemiology Unit
Caroline S. Fox - Framingham Heart Study
Rune Frants - Leiden University
Maria Grazia Franzosi - Mario Negri Institute for Pharmacological Research
Pilar Galan - Université Sorbonne Paris Nord
Mark O. Goodarzi - Cedars-Sinai Medical Center
Juergen Graessler - TU Dresden
Christopher J. Groves - University of Oxford
Scott Grundy - The University of Texas Southwestern Medical Center
Rhian Gwilliam - Wellcome Sanger Institute
Ulf Gyllensten - Uppsala University
Samy Hadjadj - University of Poitiers
Goeran Hallmans - Umeå University
Naomi Hammond - Wellcome Sanger Institute
Xijing Han - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Anna-Liisa Hartikainen - University of Oulu
Neelam Hassanali - University of Oxford
Caroline Hayward - College Station Medical Center
Simon C. Heath - Evry
Serge Hercberg - Descartes
Christian Herder - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany
Andrew A. Hicks - College Station Medical Center
David R. Hillman - College Station Medical Center
Aroon D. Hingorani - UCL, Dept Epidemiol & Publ Hlth, London, England
Albert Hofman - College Station Medical Center
Jennie Hui - College Station Medical Center
Joe Hung - Sir Charles Gairdner Hosp, Heart Inst Western Australia, Nedlands, WA 6009, Australia
Bo Isomaa - Folkhalsan Res Ctr, Helsinki, Finland
Paul R. V. Johnson - University of Oxford
Torben Jorgensen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Antti Jula - Natl Inst Hlth & Welf, Unit Populat Studies, Turku, Finland
Marika Kaakinen - University of Oulu
Jaakko Kaprio - University of Helsinki
Y. Antero Kesaniemi - University of Oulu
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, London, England
Beatrice Knight - University of Exeter
Seppo Koskinen - Natl Inst Hlth & Welf, Unit Living Condit Hlth & Wellbeing, Helsinki, Finland
Peter Kovacs - Univ Leipzig, Interdisciplinary Ctr Clin Res, Leipzig, Germany
Kirsten Ohm Kyvik - Univ So Denmark, Inst Publ Hlth, Danish Twin Registry, Odense, Denmark
G. Mark Lathrop - Evry
Debbie A. Lawlor - University of Bristol
Olivier Le Bacquer - Univ Lille 2, Inst Pasteur, CNRS, Unite Mixte Rech 8090, Lille, France
Cecile Lecoeur - University of Lille
Yun Li - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Valeriya Lyssenko - Supreme Council Of Health
Robert Mahley - Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94143 USA
Massimo Mangino - Kings Coll London, Twin Res & Genet Epidemiol Dept, London WC2R 2LS, England
Alisa K. Manning - Boston University
Maria Teresa Martinez-Larrad - Hosp Clin San Carlos, Fdn Invest Biomed, Madrid, Spain
Jarred B. McAteer - Broad Institute
Laura J. McCulloch - University of Oxford
Ruth McPherson - University of Ottawa
Christa Meisinger - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol, Neuherberg, Germany
David Melzer - University of Exeter
David Meyre - Univ Lille 2, Inst Pasteur, CNRS, Unite Mixte Rech 8090, Lille, France
Braxton D. Mitchell - Supreme Council Of Health
Mario A. Morken - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Sutapa Mukherjee - College Station Medical Center
Silvia Naitza - Cittadella Univ Monserrato, CNR, INN, Cagliari, Italy
Narisu Narisu - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Matthew J. Neville - University of Oxford
Ben A. Oostra - College Station Medical Center
Marco Orru - Cittadella Univ Monserrato, CNR, INN, Cagliari, Italy
Ruth Pakyz - Supreme Council Of Health
Colin N. A. Palmer - University of Dundee
Giuseppe Paolisso - College Station Medical Center
Cristian Pattaro - College Station Medical Center
Daniel Pearson - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
John F. Peden - University of Oxford
Nancy L. Pedersen - Karolinska Institutet
Markus Perola - University of Helsinki
Andreas F. H. Pfeiffer - Charité - Universitätsmedizin Berlin
Irene Pichler - College Station Medical Center
Ozren Polasek - University of Zagreb
Danielle Posthuma - University of Amsterdam
Simon C. Potter - Wellcome Sanger Institute
Anneli Pouta - Oulu Univ Hosp, Dept Obstet & Gynaecol, Oulu, Finland
Michael A. Province - Supreme Council Of Health
Bruce M. Psaty - University of Washington
Wolfgang Rathmann - Univ Dusseldorf, Leibniz Ctr, German Diabet Ctr, Inst Biometr & Epidemiol, Dusseldorf, Germany
Nigel W. Rayner - University of Oxford
Kenneth Rice - University of Washington
Samuli Ripatti - University of Helsinki
Fernando Rivadeneira - College Station Medical Center
Michael Roden - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany
Olov Rolandsson - Umeå University
Annelli Sandbaek - Supreme Council Of Health
Manjinder Sandhu - Massachusetts Rehabilitation Commission
Serena Sanna - Cittadella Univ Monserrato, CNR, INN, Cagliari, Italy
Avan Aihie Sayer - University of Southampton
Paul Scheet - Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
Laura J. Scott - Biostat
Udo Seedorf - University of Münster
Stephen J. Sharp - Massachusetts Rehabilitation Commission
Beverley Shields - University of Exeter
Gunnar Sigurosson - Landspitali Univ Hosp, Reykjavik, Iceland
Eric J. G. Sijbrands - College Station Medical Center
Angela Silveira - Karolinska Institutet
Laila Simpson - University of Western Australia
Andrew Singleton - NIA, Neurogenet Lab, Bethesda, MD 20892 USA
Nicholas L. Smith - University of Washington
Ulla Sovio - University of London
Amy Swift - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Holly Syddall - University of Southampton
Ann-Christine Syvanen - Uppsala University
Toshiko Tanaka - MedStar Res Inst, Baltimore, MD USA
Barbara Thorand - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol, Neuherberg, Germany
Jean Tichet - Inst Interreg Sante IRSA, La Riche, France
Anke Tonjes - College Station Medical Center
Tiinamaija Tuomi - Folkhalsan Res Ctr, Helsinki, Finland
Andre G. Uitterlinden - College Station Medical Center
Ko Willems van Dijk - Leiden University
Mandy van Hoek - College Station Medical Center
Dhiraj Varma - Wellcome Sanger Institute
Sophie Visvikis-Siest - Nancy Univ Henri Poincare, Res Unit, Nancy, France
Veronique Vitart - College Station Medical Center
Nicole Vogelzangs - University of Amsterdam
Gerard Waeber - College Station Medical Center
Peter J. Wagner - University of Helsinki
Andrew Walley - University of London
G. Bragi Walters - deCODE Genet, Reykjavik, Iceland
Kim L. Ward - University of Western Australia
Hugh Watkins - University of Oxford
Michael N. Weedon - University of Exeter
Sarah H. Wild - University of Edinburgh
Gonneke Willemsen - University of Amsterdam
Jaqueline C. M. Witteman - College Station Medical Center
John W. G. Yarnell - Queens University
Eleftheria Zeggini - University of Oxford
Diana Zelenika - Evry
Bjorn Zethelius - Uppsala University
Guangju Zhai - Kings Coll London, Twin Res & Genet Epidemiol Dept, London WC2R 2LS, England
Jing Hua Zhao - Massachusetts Rehabilitation Commission
M. Carola Zillikens - College Station Medical Center
Ingrid B. Borecki - Supreme Council Of Health
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Pierre Meneton - Descartes
Patrik K. E. Magnusson - Karolinska Institutet
David M. Nathan - Massachusetts Gen Hosp, Diabet Unit, Diabet Res Ctr, Boston, MA 02114 USA
Gordon H. Williams - Harvard University
Andrew T. Hattersley - University of Exeter
Kaisa Silander - University of Helsinki
Veikko Salomaa - Natl Inst Hlth & Welf, Unit Chron Dis Epidemiol & Prevent, Helsinki, Finland
George Davey Smith - University of Bristol
Stefan R. Bornstein - College Station Medical Center
Peter Schwarz - College Station Medical Center
Joachim Spranger - Charité - Universitätsmedizin Berlin
Fredrik Karpe - University of Oxford
Alan R. Shuldiner - Supreme Council Of Health
Cyrus Cooper - University of Southampton
George V. Dedoussis - Harokopio University of Athens
Manuel Serrano-Rios - Hosp Clin San Carlos, Fdn Invest Biomed, Madrid, Spain
Andrew D. Morris - University of Dundee
Lars Lind - Uppsala University
Lyle J. Palmer - University of Western Australia
Frank B. Hu - Harvard University
Paul W. Franks - Umeå University
Shah Ebrahim - Supreme Council Of Health
Michael Marmot - UCL, Dept Epidemiol & Publ Hlth, London, England
W. H. Linda Kao - Johns Hopkins University
James S. Pankow - University of Minnesota
Michael J. Sampson - Norwich University
Johanna Kuusisto - College Station Medical Center
Markku Laakso - College Station Medical Center
Torben Hansen - Hagedorn Res Inst, Gentofte, Denmark
Oluf Pedersen - Hagedorn Res Inst, Gentofte, Denmark
Peter Paul Pramstaller - College Station Medical Center
H. Erich Wichmann - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol, Neuherberg, Germany
Thomas Illig - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol, Neuherberg, Germany
Igor Rudan - University of Edinburgh
Alan F. Wright - College Station Medical Center
Michael Stumvoll - College Station Medical Center
Harry Campbell - University of Edinburgh
James F. Wilson - University of Edinburgh
Richard N. Bergman - Supreme Council Of Health
Thomas A. Buchanan - Supreme Council Of Health
Francis S. Collins - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Jaakko Tuomilehto - University of Helsinki
Timo T. Valle - Natl Inst Hlth & Welf, Unit Diabet Prevent, Helsinki, Finland
David Altshuler - Broad Institute
Jerome I. Rotter - College Station Medical Center
David S. Siscovick - S Ostrobothnia Cent Hosp, Seinajoki, Finland
Brenda W. J. H. Penninx - University of Amsterdam
Dorret I. Boomsma - University of Amsterdam
Panos Deloukas - Wellcome Sanger Institute
Timothy D. Spector - Wellcome Sanger Institute
Timothy M. Frayling - University of Exeter
Luigi Ferrucci - University of Washington
Augustine Kong - deCODE Genet, Reykjavik, Iceland
Unnur Thorsteinsdottir - deCODE Genet, Reykjavik, Iceland
Kari Stefansson - deCODE Genet, Reykjavik, Iceland
Cornelia M. van Duijn - College Station Medical Center
Yurii S. Aulchenko - College Station Medical Center
Antonio Cao - Cittadella Univ Monserrato, CNR, INN, Cagliari, Italy
Angelo Scuteri - Cittadella Univ Monserrato, CNR, INN, Cagliari, Italy
David Schlessinger - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Manuela Uda - Cittadella Univ Monserrato, CNR, INN, Cagliari, Italy
Aimo Ruokonen - NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA
Marjo-Riitta Jarvelin - University of London
Dawn M. Waterworth - GlaxoSmithKline
Peter Vollenweider - College Station Medical Center
Leena Peltonen - Wellcome Sanger Institute
Vincent Mooser - GlaxoSmithKline
Goncalo R. Abecasis - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
Robert Sladek - McGill University
Philippe Froguel - University of Lille
Richard M. Watanabe - Supreme Council Of Health
James B. Meigs - College Station Medical Center
Leif Groop - Malmö University
Michael Boehnke - Biostat
Mark I. McCarthy - University of Oxford
Jose C. Florez - Broad Institute
Ines Barroso - Wellcome Sanger Institute
DIAGRAM Consortium
Publication Details: Nature genetics, Vol.42(2), pp.105-U32
Publisher: Springer Nature
Number of pages: 15
Grant note: G0601261 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) P30 DK040561-14; R01 DK029867; K24 DK080140; R01 DK078616; R01 DK072193; P30 DK040561; R01 DK078616-01A1 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U1475000002 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission 089061; 091746; 064890; 077011; 077016; 088885; 081682; 090532 / Wellcome Trust; European Commission ES/G007438/1 / ESRC; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) NF-SI-0508-10082 / National Institute for Health Research; National Institute for Health Research (NIHR) MC_U106179471; MC_UP_A620_1014; G0801056; G0600331; G0600705; G0601261; MC_U106188470; G0700222; G0701863; MC_U137686857; G0902037; G8802774; MC_U127561128; G0700222(81696); G0100222; G19/35; MC_UP_A620_1015; MC_U127592696 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission R01DK072193 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) CZB/4/710 / Chief Scientist Office ZIAAG000675 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) RG/07/008/23674 / British Heart Foundation R69/0208 / The Dunhill Medical Trust; Dunhill Medical Trust ES/G007438/1 / Economic and Social Research Council; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) ZIAHG000024 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
Identifiers: 9938077608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article