New genetic loci link adipose and insulin biology to body fat distribution

Dmitry Shungin; Thomas W. Winkler; Damien C. Croteau-Chonka; Teresa Ferreira; Adam E. Lockes; Reedik Maegi; Rona J. Strawbridge; Tune H. Pers; Krista Fischer; Anne E. Justice; Tsegaselassie Workalemahu; Joseph M. W. Wu; Martin L. Buchkovich; Nancy L. Heard-Costa; Tamara S. Roman; Alexander W. Drong; Ci Song; Stefan Gustafsson; Felix R. Day; Tonu Esko; Tove Fall; Zoltan Kutalik; Jian'an Luan; Joshua C. Randall; Andre Scherag; Sailaja Vedantam; Andrew R. Wood; Jin Chen; Rudolf Fehrmann; Juha Karjalainen; Bratati Kahali; Ching-Ti Liu; Ellen M. Schmidt; Devin Absher; Najaf Amin; Denise Anderson; Marian Beekman; Jennifer L. Bragg-Gresham; Steven Buyske; Ayse Demirkan; Georg B. Ehret; Mary F. Feitosa; Anuj Goel; Anne U. Jackson; Toby Johnson; Marcus E. Kleber; Kati Kristiansson; Massimo Mangino; Irene Mateo Leach; Carolina Medina-Gomez; Cameron D. Palmer; Dorota Pasko; Sonali Pechlivaniss; Marjolein J. Peters; Inga Prokopenko; Alena Stancakova; Yun Ju Sung; Toshiko Tanakam; Alexander Teumer; Jana V. Van Vliet-Ostaptchouk; Loic Yengo; Weihua Zhang; Eva Albrecht; Johan Arnlov; Gillian M. Arscott; Stefania Bandinelli; Amy Barrett; Claire Bellis; Amanda J. Bennett; Christian Berne; Matthias Blueher; Stefan Buhringer; Fabrice Bonnet; Yvonne Boettcher; Marcel Bruinenberg; Delia B. Carba; Ida H. Caspersen; Robert Clarke; E. Warwick Daw; Joris Deelen; Ewa Deelman; Graciela Delgado; Alex S. F. Doney; Niina Eklund; Michael R. Erdos; Karol Estrada; Elodie Eury; Nele Friedrichs; Melissa E. Garcia; Vilmantas Giedraitis; Bruna Gigante; Alan S. Go; Alain Golay; Harald Grallert; Tanja B. Grammer; Juergen Graessler; Jagvir Grewal; Christopher J. Groves; Toomas Haller; Goran Hallmans; Catharina A. Hartman; Maija Hassinen; Caroline Hayward; Kauko Heikkila; Karl-Heinz Herzig; Quinta Helmer; Hans L. Hillege; Oddgeir Holmen; Steven C. Hunt; Aaron Isaacs; Till Ittermann; Alan L. James; Ingegerd Johansson; Thorhildur Juliusdottir; Ioanna-Panagiota Kalafati; Leena Kinnunen; Wolfgang Koenig; Ishminder K. Kooner; Wolfgang Kratzer; Claudia Lamina; Karin Leander; Nanette R. Lee; Peter Lichtner; Lars Lind; Jaana Lindstrom; Stephane Lobbens; Mattias Lorentzon; Francois Mach; Patrik K. E. Magnusson; Anubha Mahajan; Wendy L. McArdle; Cristina Menni; Sigrun Merger; Evelin Mihailov; Lili Milani; Rebecca Mills; Alireza Moayyeri; Ken L. Monda; Simon P. Mooijaart; Thomas W. Muehleisen; Antonella Mulas; Gabriele Mueller; Martina Mueller-Nurasyid; Ramaiah Nagaraja; Michael A. Nalls; Narisu Narisu; Nicola Glorioso; Ilja M. Nolte; Matthias Olden; Nigel W. Rayner; Frida Renstrom; Janina S. Ried; Neil R. Robertson; Lynda M. Rose; Serena Sanna; Hubert Scharnagl; Salome Scholtens; Bengt Sennblad; Thomas Seufferlein; Colleen M. Sitlani; Albert Vernon Smith; Kathleen Stirrups; Heather M. Stringham; Johan Sundstrom; Morris A. Swertz; Amy J. Swift; Ann-Christine Syvanen; Bamidele O. Tayo; Barbara Thorand; Gudmar Thorleifsson; Andreas Tomaschitz; Chiara Troffa; Floor V. A. van Oort; Niek Verweij; Judith M. Vonk; Lindsay L. Waite; Roman Wennauer; Tom Wilsgaard; Mary K. Wojczynski; Andrew Wong; Qunyuan Zhang; Jing Hua Zhao; Eoin P. Brennan; Murim Choi; Per Eriksson; Lasse Folkersen; Anders Franco-Cereceda; Ali G. Gharavi; Asa K. Hedman; Marie-France Hivert; Jinyan Huang; Stavroula Kanoni; Fredrik Karpe; Sarah Keildson; Krzysztof Kiryluk; Liming Liang; Richard P. Lifton; Baoshan Ma; Amy J. McKnight; Ruth McPherson; Andres Metspalu; Josine L. Min; Miriam F. Moffatt; Grant W. Montgomery; Joanne M. Murabito; George Nicholson; Dale R. Nyholt; Christian Olsson; John R. B. Perry; Eva Reinmaa; Rany M. Salem; Niina Sandholm; Eric E. Schadt; Robert A. Scott; Lisette Stolk; Edgar E. Vallejo; Harm-Jan Westra; Krina T. Zondervan; Philippe Amouyel; Dominique Arveiler; Stephan J. L. Bakker; John Beilby; Richard N. Bergman; John Blangero; Morris J. Brown; Michel Burnier; Harry Campbell; Aravinda Chakravarti; Peter S. Chiness; Simone Claudi-Boehmi; Francis S. Collins; Dana C. Crawford; John Danesh; Ulf de Faire; Eco J. C. de Geusl; Marcus Doerr; Raimund Erbel; Johan G. Eriksson; Martin Farrall; Ele Ferrannini; Jean Ferrieres; Nita G. Forouhi; Terrence Forrester; Oscar H. Franco; Ron T. Gansevoort; Christian Gieger; Vilmundur Gudnason; Christopher A. Haiman; Tamara B. Harris; Andrew T. Hattersley; Markku Heliovaara; Andrew A. Hicks; Aroon D. Hingorani; Wolfgang Hoffmann; Albert Hofman; Georg Homuth; Steve E. Humphries; Elina Hyppoenen; Thomas Illig; Marjo-Riitta Jarvelin; Berit Johansen; Pekka Jousilahti; Antti M. Jula; Jaakko Kaprio; Frank Kee; Sirkka M. Keinanen-Kiukaanniemi; Jaspal S. Kooner; Charles Kooperberg; Peter Kovacs; Aldi T. Kraja; Meena Kumari; Kari Kuulasmaa; Johanna Kuusisto; Timo A. Lakka; Claudia Langenberg; Loic Le Marchand; Terho Lehtimaki; Valeriya Lyssenko; Satu Mannisto; Andre Marette; Tara C. Matise; Colin A. McKenzie; Barbara McKnight; Arthur W. Musk; Stefan Mohlenkamp; Andrew D. Morris; Mari Nelis; Claes Ohlsson; Albertine J. Oldehinkel; Ken K. Ong; Lyle J. Palmer; Brenda W. Penninx; Annette Peters; Peter P. Pramstaller; Olli T. Raitakari; Tuomo Rankinen; D. C. Rao; Treva K. Rice; Paul M. Ridker; Marylyn D. Ritchie; Igor Rudan; Veikko Salomaa; Nilesh J. Samani; Jouko Saramies; Mark A. Sarzynski; Peter E. H. Schwarz; Alan R. Shuldiner; Jan A. Staessen; Valgerdur Steinthorsdottir; Ronald P. Stolk; Konstantin Strauch; Anke Toenjes; Angelo Tremblay; Elena Tremoli; Marie-Claude Vohl; Uwe Voelker; Peter Vollenweider; James F. Wilson; Jacqueline C. Witteman; Linda S. Adair; Murielle Bochud; Bernhard O. Boehm; Stefan R. Bornstein; Claude Bouchard; Stephane Cauchi; Mark J. Caulfield; John C. Chambers; Daniel I. Chasman; Richard S. Cooper; George Dedoussis; Luigi Ferrucci; Philippe Froguel; Hans-Joergen Grabe; Anders Hamsten; Jennie Hui; Kristian Hveem; Karl-Heinz Joeckel; Mika Kivimaki; Diana Kuh; Markku Laakso; Yongmei Liu; Winfried Maerz; Patricia B. Munroe; Inger Njolstad; Ben A. Oostra; Colin N. A. Palmer; Nancy L. Pedersen; Markus Perola; Louis Perusse; Ulrike Peters; Chris Power; Thomas Quertermous; Rainer Rauramaa; Fernando Rivadeneira; Timo E. Saaristo; Danish Saleheen; Juha Sinisalo; P. Eline Slagboom; Harold Snieder; Tim D. Spector; Unnur R. Thorsteinsdottir; Michael Stumvoll; Jaakko Tuomilehto; Andre G. Uitterlinden; Math Uusitupa; Pim van der Harst; Giovanni Veronesi; Mark Walker; Nicholas J. Wareham; Hugh Watkins; H-Erich Wichmann; Goncalo R. Abecasis; Themistocles L. Assimes; Sonja I. Berndt; Michael Boehnkes; Ingrid B. Borecki; Panos Deloukas; Lude Franke; Timothy M. Frayling; Leif C. Groop; David J. Hunter; Robert C. Kaplan; Jeffrey R. O'Connell; Lu Qi; David Schlessinger; David P. Strachan; Kari Stefansson; Cornelia M. van Dujin; Cristen J. Willer; Peter M. Visscher; Jian Yang; Joel N. Hirschhorn; M. Carola Zillikens; Mark I. McCarthy; Elizabeth K. Speliotes; Kari E. North; Caroline S. Fox; Ines Barroso; Paul W. Franks; Erik Ingelsson; Iris M. Heid; Ruth J. F. Loos; L. Adrienne Cupples; Andrew P. Morris; Cecilia M. Lindgren; Karen L. Mohlke; PAGE Consortium

doi:10.1038/nature14132

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New genetic loci link adipose and insulin biology to body fat distribution

Journal article

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New genetic loci link adipose and insulin biology to body fat distribution

Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau-Chonka, Teresa Ferreira, Adam E. Lockes, Reedik Maegi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, …

Nature (London), Vol.518(7538), pp.187-U378

12/02/2015

DOI: https://doi.org/10.1038/nature14132

PMCID: PMC4338562

PMID: 25673412

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 x 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

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Title: New genetic loci link adipose and insulin biology to body fat distribution
Creators - without role: Dmitry Shungin - Umeå University
Thomas W. Winkler - University of Regensburg
Damien C. Croteau-Chonka - Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
Teresa Ferreira - University of Oxford
Adam E. Lockes - Biostat
Reedik Maegi - University of Oxford
Rona J. Strawbridge - Karolinska Institutet
Tune H. Pers - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Krista Fischer - University of Tartu
Anne E. Justice - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
Tsegaselassie Workalemahu - Harvard University
Joseph M. W. Wu - Boston University
Martin L. Buchkovich - Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
Nancy L. Heard-Costa - Framingham Heart Study
Tamara S. Roman - Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
Alexander W. Drong - University of Oxford
Ci Song - Karolinska Institutet
Stefan Gustafsson - Uppsala University
Felix R. Day - University of Cambridge
Tonu Esko - University of Tartu
Tove Fall - Karolinska Institutet
Zoltan Kutalik - College Station Medical Center
Jian'an Luan - University of Cambridge
Joshua C. Randall - University of Oxford
Andre Scherag - Univ Hosp Essen, IMIBE, D-45147 Essen, Germany
Sailaja Vedantam - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Andrew R. Wood - University of Exeter
Jin Chen - College Station Medical Center
Rudolf Fehrmann - University of Groningen
Juha Karjalainen - University of Groningen
Bratati Kahali - College Station Medical Center
Ching-Ti Liu - Boston University
Ellen M. Schmidt - College Station Medical Center
Devin Absher - HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA
Najaf Amin - Erasmus MC
Denise Anderson - University of Western Australia
Marian Beekman - Leiden University
Jennifer L. Bragg-Gresham - Biostat
Steven Buyske - Biostat
Ayse Demirkan - Erasmus MC
Georg B. Ehret - Johns Hopkins University
Mary F. Feitosa - Supreme Council Of Health
Anuj Goel - University of Oxford
Anne U. Jackson - Biostat
Toby Johnson - Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland
Marcus E. Kleber - Heidelberg University
Kati Kristiansson - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Irene Mateo Leach - University of Groningen
Carolina Medina-Gomez - NCHA, NL-3015 GE Rotterdam, Netherlands
Cameron D. Palmer - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Dorota Pasko - University of Exeter
Sonali Pechlivaniss - Univ Hosp Essen, IMIBE, D-45147 Essen, Germany
Marjolein J. Peters - NCHA, NL-3015 GE Rotterdam, Netherlands
Inga Prokopenko - University of Oxford
Alena Stancakova - University of Eastern Finland
Yun Ju Sung - Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
Toshiko Tanakam - NIA, Translat Gerontol Branch, Baltimore, MD 21225 USA
Alexander Teumer - College Station Medical Center
Jana V. Van Vliet-Ostaptchouk - University of Groningen
Loic Yengo - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Weihua Zhang - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Eva Albrecht - Helmholtz Zentrum München
Johan Arnlov - Uppsala University
Gillian M. Arscott - College Station Medical Center
Stefania Bandinelli - Florence
Amy Barrett - University of Oxford
Claire Bellis - Texas Biomedical Research Institute
Amanda J. Bennett - University of Oxford
Christian Berne - Uppsala University
Matthias Blueher - Institute of Inland Fisheries in Potsdam-Sacrow
Stefan Buhringer - Leiden University
Fabrice Bonnet - University of Rennes
Yvonne Boettcher - Institute of Inland Fisheries in Potsdam-Sacrow
Marcel Bruinenberg - University of Groningen
Delia B. Carba - University of San Carlos
Ida H. Caspersen - Norwegian Univ Sci & Technol, Dept Biol, N-7491 Trondheim, Norway
Robert Clarke - University of Oxford
E. Warwick Daw - Supreme Council Of Health
Joris Deelen - Leiden University
Ewa Deelman - Univ So Calif, Inst Informat Sci, Marina Del Rey, CA 90292 USA
Graciela Delgado - Heidelberg University
Alex S. F. Doney - University of Dundee
Niina Eklund - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Michael R. Erdos - College Station Medical Center
Karol Estrada - Broad Institute
Elodie Eury - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Nele Friedrichs - College Station Medical Center
Melissa E. Garcia - NIA, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA
Vilmantas Giedraitis - Uppsala University
Bruna Gigante - Karolinska Institutet
Alan S. Go - Kaiser Permanente
Alain Golay - Univ Hosp Geneva, Serv Therapeut Educ Diabet Obes & Chron Dis, CH-1211 Geneva, Switzerland
Harald Grallert - Helmholtz Zentrum München
Tanja B. Grammer - Heidelberg University
Juergen Graessler - College Station Medical Center
Jagvir Grewal - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Christopher J. Groves - University of Oxford
Toomas Haller - University of Tartu
Goran Hallmans - Umeå University
Catharina A. Hartman - University of Groningen
Maija Hassinen - College Station Medical Center
Caroline Hayward - University of Edinburgh
Kauko Heikkila - University of Helsinki
Karl-Heinz Herzig - University of Oulu
Quinta Helmer - Leiden University
Hans L. Hillege - University of Groningen
Oddgeir Holmen - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7489 Trondheim, Norway
Steven C. Hunt - University of Utah
Aaron Isaacs - Erasmus MC
Till Ittermann - College Station Medical Center
Alan L. James - College Station Medical Center
Ingegerd Johansson - Umeå University
Thorhildur Juliusdottir - University of Oxford
Ioanna-Panagiota Kalafati - Harokopio University of Athens
Leena Kinnunen - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Wolfgang Koenig - University of Ulm
Ishminder K. Kooner - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Wolfgang Kratzer - University of Ulm
Claudia Lamina - College Station Medical Center
Karin Leander - Karolinska Institutet
Nanette R. Lee - University of San Carlos
Peter Lichtner - Helmholtz Zentrum München
Lars Lind - Uppsala University
Jaana Lindstrom - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Stephane Lobbens - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Mattias Lorentzon - University of Gothenburg
Francois Mach
Patrik K. E. Magnusson - Karolinska Institutet
Anubha Mahajan - University of Oxford
Wendy L. McArdle - University of Bristol
Cristina Menni - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Sigrun Merger - University of Ulm
Evelin Mihailov - University of Tartu
Lili Milani - University of Tartu
Rebecca Mills - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Alireza Moayyeri - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Ken L. Monda - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
Simon P. Mooijaart - Leiden University
Thomas W. Muehleisen - University of Bonn
Antonella Mulas - CNR, IRGB, I-09042 Cagliari, Sardinia, Italy
Gabriele Mueller - Evidence
Martina Mueller-Nurasyid - Helmholtz Zentrum München
Ramaiah Nagaraja - NIA, Genet Lab, Baltimore, MD 21224 USA
Michael A. Nalls - NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Narisu Narisu - College Station Medical Center
Nicola Glorioso - University of Sassari
Ilja M. Nolte - University of Groningen
Matthias Olden - University of Regensburg
Nigel W. Rayner - University of Oxford
Frida Renstrom - Lund University
Janina S. Ried - Helmholtz Zentrum München
Neil R. Robertson - University of Oxford
Lynda M. Rose - Brigham and Women's Hospital
Serena Sanna - CNR, IRGB, I-09042 Cagliari, Sardinia, Italy
Hubert Scharnagl - University of Graz
Salome Scholtens - University of Groningen
Bengt Sennblad - Karolinska Institutet
Thomas Seufferlein - University of Ulm
Colleen M. Sitlani - University of Washington
Albert Vernon Smith - Heidelberg Univ, Dept Med Nephrol Hypertensiol Endocrinol Diabetol, Med Fac Mannheim, D-68187 Mannheim, Germany
Kathleen Stirrups - Wellcome Sanger Institute
Heather M. Stringham - Biostat
Johan Sundstrom - Uppsala University
Morris A. Swertz - University of Groningen
Amy J. Swift - College Station Medical Center
Ann-Christine Syvanen - Uppsala University
Bamidele O. Tayo - Loyola University Chicago
Barbara Thorand - German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany
Gudmar Thorleifsson - Amgen
Andreas Tomaschitz - University of Graz
Chiara Troffa - University of Sassari
Floor V. A. van Oort - Erasmus MC
Niek Verweij - University of Groningen
Judith M. Vonk - University of Groningen
Lindsay L. Waite - HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA
Roman Wennauer - University of Ulm
Tom Wilsgaard - UiT The Arctic University of Norway
Mary K. Wojczynski
Andrew Wong - Massachusetts Rehabilitation Commission
Qunyuan Zhang - Supreme Council Of Health
Jing Hua Zhao - University of Cambridge
Eoin P. Brennan - Supreme Council Of Health
Murim Choi - College Station Medical Center
Per Eriksson - Karolinska Institutet
Lasse Folkersen - Karolinska Institutet
Anders Franco-Cereceda - Karolinska Institutet
Ali G. Gharavi - Columbia University
Asa K. Hedman - University of Oxford
Marie-France Hivert - Harvard University
Jinyan Huang - Shanghai Jiao Tong University
Stavroula Kanoni - Queen Mary University of London
Fredrik Karpe - University of Oxford
Sarah Keildson - University of Oxford
Krzysztof Kiryluk - Columbia University
Liming Liang - Harvard University
Richard P. Lifton - Yale University
Baoshan Ma - Harvard University
Amy J. McKnight - Queens University
Ruth McPherson - University of Ottawa
Andres Metspalu - University of Tartu
Josine L. Min - University of Bristol
Miriam F. Moffatt - University of London
Grant W. Montgomery - College Station Medical Center
Joanne M. Murabito - Framingham Heart Study
George Nicholson - University of Oxford
Dale R. Nyholt - College Station Medical Center
Christian Olsson - Karolinska Institutet
John R. B. Perry - University of Oxford
Eva Reinmaa - University of Tartu
Rany M. Salem - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Niina Sandholm - Aalto University
Eric E. Schadt - Supreme Council Of Health
Robert A. Scott - University of Cambridge
Lisette Stolk - Leiden University
Edgar E. Vallejo - Tecnol Monterrey, Dept Comp Sci, Atizapan De Zaragoza 52926, Mexico
Harm-Jan Westra - University of Groningen
Krina T. Zondervan - University of Oxford
Philippe Amouyel - Univ Lille 2, Inst Pasteur Lille, INSERM, U744, F-59000 Lille, France
Dominique Arveiler - University of Strasbourg
Stephan J. L. Bakker - University of Groningen
John Beilby - College Station Medical Center
Richard N. Bergman - Cedars Sinai Diabet & Obes Res Inst, Los Angeles, CA 90048 USA
John Blangero - Texas Biomedical Research Institute
Morris J. Brown - University of Cambridge
Michel Burnier - College Station Medical Center
Harry Campbell - University of Edinburgh
Aravinda Chakravarti - Johns Hopkins University
Peter S. Chiness - College Station Medical Center
Simone Claudi-Boehmi - University of Ulm
Francis S. Collins - College Station Medical Center
Dana C. Crawford - Vanderbilt University
John Danesh - University of Cambridge
Ulf de Faire - Karolinska Institutet
Eco J. C. de Geusl - University of Amsterdam
Marcus Doerr - College Station Medical Center
Raimund Erbel - Univ Hosp Essen, West German Heart Ctr, Clin Cardiol, D-45122 Essen, Germany
Johan G. Eriksson - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Martin Farrall - University of Oxford
Ele Ferrannini - University of Pisa
Jean Ferrieres - Supreme Council Of Health
Nita G. Forouhi - University of Cambridge
Terrence Forrester - Univ W Indies, UWI Solut Developing Countries, Kingston 7, Jamaica
Oscar H. Franco - NCHA, NL-3015 GE Rotterdam, Netherlands
Ron T. Gansevoort - University of Groningen
Christian Gieger - Helmholtz Zentrum München
Vilmundur Gudnason - Iceland Heart Assoc, IS-201 Kopavogur, Iceland
Christopher A. Haiman - Supreme Council Of Health
Tamara B. Harris - NIA, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA
Andrew T. Hattersley - University of Exeter
Markku Heliovaara - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Andrew A. Hicks - Bolzano EURAC, European Acad Bozen, Ctr Biomed, I-39100 Bolzano, Italy
Aroon D. Hingorani - UCL, Inst Cardiovasc Sci, London WC1E 6BT, England
Wolfgang Hoffmann - College Station Medical Center
Albert Hofman - NCHA, NL-3015 GE Rotterdam, Netherlands
Georg Homuth - College Station Medical Center
Steve E. Humphries - UCL, Ctr Cardiovasc Genet, Inst Cardiovasc Sci, London WC1E 6JJ, England
Elina Hyppoenen - Univ S Australia, Sansom Inst Hlth Res, Adelaide, SA 5000, Australia
Thomas Illig - Helmholtz Zentrum München
Marjo-Riitta Jarvelin - University of London
Berit Johansen - Norwegian Univ Sci & Technol, Dept Biol, N-7491 Trondheim, Norway
Pekka Jousilahti - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Antti M. Jula - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Jaakko Kaprio - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Frank Kee - Queens University
Sirkka M. Keinanen-Kiukaanniemi - University of Oulu
Jaspal S. Kooner - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Charles Kooperberg - Hutchinson
Peter Kovacs - Institute of Inland Fisheries in Potsdam-Sacrow
Aldi T. Kraja - Supreme Council Of Health
Meena Kumari - UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England
Kari Kuulasmaa - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Johanna Kuusisto - College Station Medical Center
Timo A. Lakka - College Station Medical Center
Claudia Langenberg - University of Cambridge
Loic Le Marchand - University of Hawaii System
Terho Lehtimaki - University of Tampere
Valeriya Lyssenko - Steno Diabet Ctr AS, DK-2820 Gentofte, Denmark
Satu Mannisto - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Andre Marette - MED Institute
Tara C. Matise - Rutgers, The State University of New Jersey
Colin A. McKenzie - Univ W Indies, UWI Solut Developing Countries, Kingston 7, Jamaica
Barbara McKnight
Arthur W. Musk - University of Washington
Stefan Mohlenkamp - Univ Hosp Essen, West German Heart Ctr, Clin Cardiol, D-45122 Essen, Germany
Andrew D. Morris - University of Dundee
Mari Nelis - University of Tartu
Claes Ohlsson - University of Gothenburg
Albertine J. Oldehinkel - University of Groningen
Ken K. Ong - University of Cambridge
Lyle J. Palmer - University of Toronto
Brenda W. Penninx - University of Amsterdam
Annette Peters - Helmholtz Zentrum München
Peter P. Pramstaller - Bolzano EURAC, European Acad Bozen, Ctr Biomed, I-39100 Bolzano, Italy
Olli T. Raitakari - College Station Medical Center
Tuomo Rankinen - Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA
D. C. Rao - Supreme Council Of Health
Treva K. Rice - Biostat
Paul M. Ridker - Brigham and Women's Hospital
Marylyn D. Ritchie - Pennsylvania State University
Igor Rudan - University of Edinburgh
Veikko Salomaa - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Nilesh J. Samani - University of Leicester
Jouko Saramies - South Carelia Cent Hosp, Lappeenranta 53130, Finland
Mark A. Sarzynski - Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA
Peter E. H. Schwarz - College Station Medical Center
Alan R. Shuldiner - Supreme Council Of Health
Jan A. Staessen - Maastricht University
Valgerdur Steinthorsdottir - Amgen
Ronald P. Stolk - University of Groningen
Konstantin Strauch - Helmholtz Zentrum München
Anke Toenjes - Institute of Inland Fisheries in Potsdam-Sacrow
Angelo Tremblay - Univ Laval, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada
Elena Tremoli - University of Milan
Marie-Claude Vohl - Univ Laval, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada
Uwe Voelker - College Station Medical Center
Peter Vollenweider - College Station Medical Center
James F. Wilson - University of Edinburgh
Jacqueline C. Witteman - Erasmus MC
Linda S. Adair - Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA
Murielle Bochud - College Station Medical Center
Bernhard O. Boehm - Supreme Council Of Health
Stefan R. Bornstein - College Station Medical Center
Claude Bouchard - Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA
Stephane Cauchi - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Mark J. Caulfield - Queen Mary University of London
John C. Chambers - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Daniel I. Chasman - Brigham and Women's Hospital
Richard S. Cooper - Loyola University Chicago
George Dedoussis - Harokopio University of Athens
Luigi Ferrucci - NIA, Translat Gerontol Branch, Baltimore, MD 21225 USA
Philippe Froguel - University of London
Hans-Joergen Grabe - Helios
Anders Hamsten - Karolinska Institutet
Jennie Hui - College Station Medical Center
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7489 Trondheim, Norway
Karl-Heinz Joeckel - Univ Hosp Essen, IMIBE, D-45147 Essen, Germany
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England
Diana Kuh - Massachusetts Rehabilitation Commission
Markku Laakso - College Station Medical Center
Yongmei Liu - Supreme Council Of Health
Winfried Maerz - Heidelberg University
Patricia B. Munroe - Queen Mary University of London
Inger Njolstad - UiT The Arctic University of Norway
Ben A. Oostra - Erasmus MC
Colin N. A. Palmer - University of Dundee
Nancy L. Pedersen - Karolinska Institutet
Markus Perola - University of Tartu
Louis Perusse - Univ Laval, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada
Ulrike Peters - Hutchinson
Chris Power - UCL, Inst Child Hlth, London WC1N 1EH, England
Thomas Quertermous - Stanford University
Rainer Rauramaa - College Station Medical Center
Fernando Rivadeneira - NCHA, NL-3015 GE Rotterdam, Netherlands
Timo E. Saaristo - Finnish Diabet Assoc, FI-33680 Tampere, Finland
Danish Saleheen - University of Cambridge
Juha Sinisalo - University of Helsinki
P. Eline Slagboom - Leiden University
Harold Snieder - University of Groningen
Tim D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Unnur R. Thorsteinsdottir - Amgen
Michael Stumvoll - Institute of Inland Fisheries in Potsdam-Sacrow
Jaakko Tuomilehto - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Andre G. Uitterlinden - NCHA, NL-3015 GE Rotterdam, Netherlands
Math Uusitupa - University of Eastern Finland
Pim van der Harst - University of Groningen
Giovanni Veronesi - University of Insubria
Mark Walker - Newcastle University
Nicholas J. Wareham - University of Cambridge
Hugh Watkins - University of Oxford
H-Erich Wichmann - College Station Medical Center
Goncalo R. Abecasis - Biostat
Themistocles L. Assimes - Stanford University
Sonja I. Berndt - NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
Michael Boehnkes - Biostat
Ingrid B. Borecki - Supreme Council Of Health
Panos Deloukas - Wellcome Sanger Institute
Lude Franke - University of Groningen
Timothy M. Frayling - University of Exeter
Leif C. Groop - University of Helsinki
David J. Hunter - Brigham and Women's Hospital
Robert C. Kaplan - Albert Einstein College of Medicine
Jeffrey R. O'Connell - Supreme Council Of Health
Lu Qi - Brigham and Women's Hospital
David Schlessinger - NIA, Genet Lab, Baltimore, MD 21224 USA
David P. Strachan - University of London
Kari Stefansson - Amgen
Cornelia M. van Dujin - Erasmus MC
Cristen J. Willer - College Station Medical Center
Peter M. Visscher - University of Queensland
Jian Yang - University of Queensland
Joel N. Hirschhorn - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
M. Carola Zillikens - NCHA, NL-3015 GE Rotterdam, Netherlands
Mark I. McCarthy - University of Oxford
Elizabeth K. Speliotes - College Station Medical Center
Kari E. North - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
Caroline S. Fox - Framingham Heart Study
Ines Barroso - Wellcome Sanger Institute
Paul W. Franks - Umeå University
Erik Ingelsson - University of Oxford
Iris M. Heid - University of Regensburg
Ruth J. F. Loos - University of Cambridge
L. Adrienne Cupples - Boston University
Andrew P. Morris - University of Oxford
Cecilia M. Lindgren - University of Oxford
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
PAGE Consortium
Publication Details: Nature (London), Vol.518(7538), pp.187-U378
Publisher: NATURE PORTFOLIO
Number of pages: 22
Grant note: NNF11OC1014855; NNF15OC0016416; NNF14OC0010513; NNF12OC1016167; NNF13OC0005785; NNF13OC0005781; NNF14OC0011039; NNF12OC1016467 / Novo Nordisk Fonden; Novo Nordisk Foundation MC_U106179472; MC_U147585819; MC_U147585827; G0600717; G0601261; MC_UU_12015/1; MC_UU_12012/1; G1000616; G0400491; MR/N01104X/1; G0902037; MC_UU_12019/1; MC_UU_12015/2; MC_PC_U127561128; MC_UU_12013/1; MR/K013351/1; MC_UP_A100_1003; MR/L003120/1; G1001799; G9521010; MC_UU_12015/5; G0601463 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) NF-SI-0512-10165; NF-SI-0513-10109; NF-SI-0611-10219; NF-SI-0508-10082; NF-SI-0611-10099; NF-SI-0512-10114; NF-SI-0513-10085; NF-SI-0512-10135; NF-SI-0507-10380; NF-SI-0512-10113; NF-SI-0611-10170; NF-SI-0514-10027 / National Institute for Health Research; National Institute for Health Research (NIHR) RG/08/008/25291; RG/08/014/24067; FS/14/55/30806; RG/13/2/30098; RG/10/12/28456; RG/07/008/23674 / British Heart Foundation ES/J023299/1; ES/F02679X/1 / ESRC; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) 14136 / Cancer Research UK CZB/4/710 / Chief Scientist Office R190-2014-3904 / Lundbeck Foundation; Lundbeckfonden ES/J023299/1; ES/F02679X/1 / Economic and Social Research Council; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) Pers Group / NNF Center for Basic Metabolic Research; Novo Nordisk Foundation MC_UU_12015/5; G0100222; G0600717B; MC_U147585819; MC_UU_12012/5/B; G0600717; G19/35; MC_UU_12015/1; G0601463; MC_U106179472; MR/K013351/1; G9521010; MC_CF023241; G0400491; G1001799; MC_U106179471; MR/N01104X/1; MC_U147585824; MC_UP_A100_1003; G0401527; MC_UU_12011/1; MR/L003120/1; MC_UU_12013/1; G8802774; MC_UP_A620_1014; MC_U147585827; MC_UU_12019/1; MC_PC_U127561128; G1000143; MR/K006584/1; MR/K011480/1; G0902037; U1475000001; MC_UU_12012/1; MC_UU_12015/2; G1000616; G0601261 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Identifiers: 9938850808331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article