New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Momoko Horikoshi; Hanieh Yaghootkar; Dennis O. Mook-Kanamori; Ulla Sovio; H. Rob Taal; Branwen J. Hennig; Jonathan P. Bradfield; Beate St Pourcain; David M. Evans; Pimphen Charoen; Marika Kaakinen; Diana L. Cousminer; Terho Lehtimaki; Eskil Kreiner-Moller; Nicole M. Warrington; Mariona Bustamante; Bjarke Feenstra; Diane J. Berry; Elisabeth Thiering; Thiemo Pfab; Sheila J. Barton; Beverley M. Shields; Marjan Kerkhof; Elisabeth M. van Leeuwen; Anthony J. Fulford; Zoltan Kutalik; Jing Hua Zhao; Marcel den Hoed; Anubha Mahajan; Virpi Lindi; Liang-Kee Goh; Jouke-Jan Hottenga; Ying Wu; Olli T. Raitakari; Marie N. Harder; Aline Meirhaeghe; Ioanna Ntalla; Rany M. Salem; Karen A. Jameson; Kaixin Zhou; Dorota M. Monies; Vasiliki Lagou; Mirna Kirin; Jani Heikkinen; Linda S. Adair; Fowzan S. Alkuraya; Ali Al-Odaib; Philippe Amouyel; Ehm Astrid Andersson; Amanda J. Bennett; Alexandra I. F. Blakemore; Jessica L. Buxton; Jean Dallongeville; Shikta Das; Eco J. C. de Geus; Xavier Estivill; Claudia Flexeder; Philippe Froguel; Frank Geller; Keith M. Godfrey; Frederic Gottrand; Christopher J. Groves; Torben Hansen; Joel N. Hirschhorn; Albert Hofman; Mads V. Hollegaard; David M. Hougaard; Elina Hyppoenen; Hazel M. Inskip; Aaron Isaacs; Torben Jorgensen; Christina Kanaka-Gantenbein; John P. Kemp; Wieland Kiess; Tuomas O. Kilpelainen; Norman Klopp; Bridget A. Knight; Christopher W. Kuzawa; George McMahon; John P. Newnham; Harri Niinikoski; Ben A. Oostra; Louise Pedersen; Dirkje S. Postma; Susan M. Ring; Fernando Rivadeneira; Neil R. Robertson; Sylvain Sebert; Olli Simell; Torsten Slowinski; Carla M. T. Tiesler; Anke Toenjes; Allan Vaag; Jorma S. Viikari; Jacqueline M. Vink; Nadja Hawwa Vissing; Nicholas J. Wareham; Gonneke Willemsen; Daniel R. Witte; Haitao Zhang; Jianhua Zhao; James F. Wilson; Michael Stumvoll; Andrew M. Prentice; Brian F. Meyer; Ewan R. Pearson; Colin A. G. Boreham; Cyrus Cooper; Matthew W. Gillman; George V. Dedoussis; Luis A. Moreno; Oluf Pedersen; Maiju Saarinen; Karen L. Mohlke; Dorret I. Boomsma; Seang-Mei Saw; Timo A. Lakka; Antje Koerner; Ruth J. F. Loos; Ken K. Ong; Peter Vollenweider; Cornelia M. van Duijn; Gerard H. Koppelman; Andrew T. Hattersley; John W. Holloway; Berthold Hocher; Joachim Heinrich; Chris Power; Mads Melbye; Monica Guxens; Craig E. Pennell; Klaus Bonnelykke; Hans Bisgaard; Johan G. Eriksson; Elisabeth Widen; Hakon Hakonarson; Andre G. Uitterlinden; Anneli Pouta; Debbie A. Lawlor; George Davey Smith; Timothy M. Frayling; Mark I. McCarthy; Struan F. A. Grant; Vincent W. V. Jaddoe; Marjo-Riitta Jarvelin; Nicholas J. Timpson; Inga Prokopenko; Rachel M. Freathy; Early Growth Genetics EGG

doi:10.1038/ng.2477

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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Momoko Horikoshi, Hanieh Yaghootkar, Dennis O. Mook-Kanamori, Ulla Sovio, H. Rob Taal, Branwen J. Hennig, Jonathan P. Bradfield, Beate St Pourcain, David M. Evans, Pimphen Charoen, …

Nature genetics, Vol.45(1), pp.76-U115

01/01/2013

DOI: https://doi.org/10.1038/ng.2477

PMCID: PMC3605762

PMID: 23202124

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

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Title: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Creators - without role: Momoko Horikoshi - University of Oxford
Hanieh Yaghootkar - University of Exeter
Dennis O. Mook-Kanamori - Erasmus MC
Ulla Sovio - University of London
H. Rob Taal - Erasmus MC
Branwen J. Hennig - Supreme Council Of Health
Jonathan P. Bradfield - Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Beate St Pourcain - University of Bristol
David M. Evans - University of Bristol
Pimphen Charoen - University of London
Marika Kaakinen - University of Oulu
Diana L. Cousminer - University of Helsinki
Terho Lehtimaki - University of Tampere
Eskil Kreiner-Moller - University of Copenhagen
Nicole M. Warrington - University of Western Australia
Mariona Bustamante - Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Bjarke Feenstra - Veterinary Biological and Research Institute
Diane J. Berry - Biostat
Elisabeth Thiering - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 1, Munich, Germany
Thiemo Pfab - Charité - Universitätsmedizin Berlin
Sheila J. Barton - University of Southampton
Beverley M. Shields - Phillips Exeter Academy
Marjan Kerkhof - University of Groningen
Elisabeth M. van Leeuwen - College Station Medical Center
Anthony J. Fulford - Supreme Council Of Health
Zoltan Kutalik - University of Lausanne
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Marcel den Hoed - Massachusetts Rehabilitation Commission
Anubha Mahajan - University of Oxford
Virpi Lindi - University of Eastern Finland
Liang-Kee Goh - Supreme Council Of Health
Jouke-Jan Hottenga - Vrije Universiteit Amsterdam
Ying Wu - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Olli T. Raitakari - University of Turku
Marie N. Harder - University of Copenhagen
Aline Meirhaeghe - Inserm
Ioanna Ntalla - Harokopio University of Athens
Rany M. Salem - Childrens Hosp, Div Genet, Boston, MA 02115 USA
Karen A. Jameson - University of Southampton
Kaixin Zhou - University of Dundee
Dorota M. Monies - King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia
Vasiliki Lagou - University of Oxford
Mirna Kirin - University of Edinburgh
Jani Heikkinen - University of Helsinki
Linda S. Adair - Univ N Carolina, Dept Nutr, Chapel Hill, NC USA
Fowzan S. Alkuraya - King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia
Ali Al-Odaib - King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia
Philippe Amouyel - Inserm
Ehm Astrid Andersson - University of Copenhagen
Amanda J. Bennett - University of Oxford
Alexandra I. F. Blakemore - University of London
Jessica L. Buxton - University of London
Jean Dallongeville - Inserm
Shikta Das - University of London
Eco J. C. de Geus - Vrije Universiteit Amsterdam
Xavier Estivill - Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Barcelona, Spain
Claudia Flexeder - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 1, Munich, Germany
Philippe Froguel - Inst Pasteur, F-59019 Lille, France
Frank Geller - Veterinary Biological and Research Institute
Keith M. Godfrey - University of Southampton
Frederic Gottrand - Univ Lille 2, Fac Med, INSERM U995, Lille, France
Christopher J. Groves - University of Oxford
Torben Hansen - University of Copenhagen
Joel N. Hirschhorn - Childrens Hosp, Div Genet, Boston, MA 02115 USA
Albert Hofman - Erasmus MC
Mads V. Hollegaard - Veterinary Biological and Research Institute
David M. Hougaard - Veterinary Biological and Research Institute
Elina Hyppoenen - Biostat
Hazel M. Inskip - University of Southampton
Aaron Isaacs - College Station Medical Center
Torben Jorgensen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Christina Kanaka-Gantenbein - National and Kapodistrian University of Athens
John P. Kemp - University of Bristol
Wieland Kiess - Univ Leipzig, Dept Womens & Child Hlth, Pediat Res Ctr, Leipzig, Germany
Tuomas O. Kilpelainen - Massachusetts Rehabilitation Commission
Norman Klopp - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Munich, Germany
Bridget A. Knight - Phillips Exeter Academy
Christopher W. Kuzawa - Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA
George McMahon - University of Bristol
John P. Newnham - University of Western Australia
Harri Niinikoski - University of Turku
Ben A. Oostra - Erasmus MC
Louise Pedersen - University of Copenhagen
Dirkje S. Postma - University of Groningen
Susan M. Ring - University of Bristol
Fernando Rivadeneira - Erasmus MC
Neil R. Robertson - University of Oxford
Sylvain Sebert - University of London
Olli Simell - University of Turku
Torsten Slowinski - Charité - Universitätsmedizin Berlin
Carla M. T. Tiesler - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 1, Munich, Germany
Anke Toenjes - College Station Medical Center
Allan Vaag - Rigshosp, Dept Endocrinol, DK-2100 Copenhagen, Denmark
Jorma S. Viikari - University of Turku
Jacqueline M. Vink - Vrije Universiteit Amsterdam
Nadja Hawwa Vissing - University of Copenhagen
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
Gonneke Willemsen - Vrije Universiteit Amsterdam
Daniel R. Witte - Steno Diabet Ctr, Gentofte, Denmark
Haitao Zhang - Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Jianhua Zhao - Childrens Hosp Philadelphia, Dept Human Genet, Philadelphia, PA 19104 USA
James F. Wilson - University of Edinburgh
Michael Stumvoll - College Station Medical Center
Andrew M. Prentice - Supreme Council Of Health
Brian F. Meyer - King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia
Ewan R. Pearson - University of Dundee
Colin A. G. Boreham - Univ Coll Dublin, Inst Sport & Hlth, Dublin 2, Ireland
Cyrus Cooper - University of Southampton
Matthew W. Gillman - Harvard University
George V. Dedoussis - Harokopio University of Athens
Luis A. Moreno - Universidad de Zaragoza
Oluf Pedersen - University of Copenhagen
Maiju Saarinen - University of Turku
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Dorret I. Boomsma - Vrije Universiteit Amsterdam
Seang-Mei Saw - Supreme Council Of Health
Timo A. Lakka - University of Eastern Finland
Antje Koerner - Univ Leipzig, Dept Womens & Child Hlth, Pediat Res Ctr, Leipzig, Germany
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Ken K. Ong - Massachusetts Rehabilitation Commission
Peter Vollenweider - College Station Medical Center
Cornelia M. van Duijn - College Station Medical Center
Gerard H. Koppelman - University of Groningen
Andrew T. Hattersley - Phillips Exeter Academy
John W. Holloway - University of Southampton
Berthold Hocher - University of Potsdam
Joachim Heinrich - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 1, Munich, Germany
Chris Power - Biostat
Mads Melbye - Veterinary Biological and Research Institute
Monica Guxens - Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Craig E. Pennell - University of Western Australia
Klaus Bonnelykke - University of Copenhagen
Hans Bisgaard - University of Copenhagen
Johan G. Eriksson - University of Helsinki
Elisabeth Widen - University of Helsinki
Hakon Hakonarson - Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Andre G. Uitterlinden - Erasmus MC
Anneli Pouta - Natl Inst Hlth & Welf, Dept Lifecourse & Serv, Oulu, Finland
Debbie A. Lawlor - University of Bristol
George Davey Smith - University of Bristol
Timothy M. Frayling - University of Exeter
Mark I. McCarthy - University of Oxford
Struan F. A. Grant - Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Vincent W. V. Jaddoe - Erasmus MC
Marjo-Riitta Jarvelin - University of London
Nicholas J. Timpson - University of Bristol
Inga Prokopenko - University of Oxford
Rachel M. Freathy - University of Exeter
Early Growth Genetics EGG
Publication Details: Nature genetics, Vol.45(1), pp.76-U115
Publisher: Springer Nature
Number of pages: 10
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Identifiers: 9918989708331
Academic Unit: King Faisal University; King Abdulaziz City for Science & Technology; King Khalid University; King Saud University; Alfaisal University
Language: English
Resource Type: Journal article