New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu; Felix R Day; Stefan Gustafsson; Martin L Buchkovich; Jianbo Na; Veronique Bataille; Diana L Cousminer; Zari Dastani; Alexander W Drong; Tõnu Esko; David M Evans; Mario Falchi; Mary F Feitosa; Teresa Ferreira; Åsa K Hedman; Robin Haring; Pirro G Hysi; Mark M Iles; Anne E Justice; Stavroula Kanoni; Vasiliki Lagou; Rui Li; Xin Li; Adam Locke; Chen Lu; Reedik Mägi; John R B Perry; Tune H Pers; Qibin Qi; Marianna Sanna; Ellen M Schmidt; William R Scott; Dmitry Shungin; Alexander Teumer; Anna A E Vinkhuyzen; Ryan W Walker; Harm-Jan Westra; Mingfeng Zhang; Weihua Zhang; Jing Hua Zhao; Zhihong Zhu; Uzma Afzal; Tarunveer Singh Ahluwalia; Stephan J L Bakker; Claire Bellis; Amélie Bonnefond; Katja Borodulin; Aron S Buchman; Tommy Cederholm; Audrey C Choh; Hyung Jin Choi; Joanne E Curran; Lisette C P G M de Groot; Philip L De Jager; Rosalie A M Dhonukshe-Rutten; Anke W Enneman; Elodie Eury; Daniel S Evans; Tom Forsen; Nele Friedrich; Frédéric Fumeron; Melissa E Garcia; Simone Gärtner; Bok-Ghee Han; Aki S Havulinna; Caroline Hayward; Dena Hernandez; Hans Hillege; Till Ittermann; Jack W Kent; Ivana Kolcic; Tiina Laatikainen; Jari Lahti; Irene Mateo Leach; Christine G Lee; Jong-Young Lee; Tian Liu; Youfang Liu; Stéphane Lobbens; Marie Loh; Leo-Pekka Lyytikäinen; Carolina Medina-Gomez; Karl Michaëlsson; Mike A Nalls; Carrie M Nielson; Laticia Oozageer; Laura Pascoe; Lavinia Paternoster; Ozren Polašek; Samuli Ripatti; Mark A Sarzynski; Chan Soo Shin; Nina Smolej Narančić; Dominik Spira; Priya Srikanth; Elisabeth Steinhagen-Thiessen; Yun Ju Sung; Karin M A Swart; Leena Taittonen; Toshiko Tanaka; Emmi Tikkanen; Nathalie van der Velde; Natasja M van Schoor; Niek Verweij; Alan F Wright; Lei Yu; Joseph M Zmuda; Niina Eklund; Terrence Forrester; Niels Grarup; Anne U Jackson; Kati Kristiansson; Teemu Kuulasmaa; Johanna Kuusisto; Peter Lichtner; Jian'an Luan; Anubha Mahajan; Satu Männistö; Cameron D Palmer; Janina S Ried; Robert A Scott; Alena Stancáková; Peter J Wagner; Ayse Demirkan; Angela Döring; Vilmundur Gudnason; Douglas P Kiel; Brigitte Kühnel; Massimo Mangino; Barbara Mcknight; Cristina Menni; Jeffrey R O'Connell; Ben A Oostra; Alan R Shuldiner; Kijoung Song; Liesbeth Vandenput; Cornelia M van Duijn; Peter Vollenweider; Charles C White; Michael Boehnke; Yvonne Boettcher; Richard S Cooper; Nita G Forouhi; Christian Gieger; Harald Grallert; Aroon Hingorani; Torben Jørgensen; Pekka Jousilahti; Mika Kivimaki; Meena Kumari; Markku Laakso; Claudia Langenberg; Allan Linneberg; Amy Luke; Colin A Mckenzie; Aarno Palotie; Oluf Pedersen; Annette Peters; Konstantin Strauch; Bamidele O Tayo; Nicholas J Wareham; David A Bennett; Lars Bertram; John Blangero; Matthias Blüher; Claude Bouchard; Harry Campbell; Nam H Cho; Steven R Cummings; Stefan A Czerwinski; Ilja Demuth; Rahel Eckardt; Johan G Eriksson; Luigi Ferrucci; Oscar H Franco; Philippe Froguel; Ron T Gansevoort; Torben Hansen; Tamara B Harris; Nicholas Hastie; Markku Heliövaara; Albert Hofman; Joanne M Jordan; Antti Jula; Mika Kähönen; Eero Kajantie; Paul B Knekt; Seppo Koskinen; Peter Kovacs; Terho Lehtimäki; Lars Lind; Yongmei Liu; Eric S Orwoll; Clive Osmond; Markus Perola; Louis Pérusse; Olli T Raitakari; Tuomo Rankinen; D C Rao; Treva K Rice; Fernando Rivadeneira; Igor Rudan; Veikko Salomaa; Thorkild I A Sørensen; Michael Stumvoll; Anke Tönjes; Bradford Towne; Gregory J Tranah; Angelo Tremblay; André G Uitterlinden; Pim van der Harst; Erkki Vartiainen; Jorma S Viikari; Veronique Vitart; Marie-Claude Vohl; Henry Völzke; Mark Walker; Henri Wallaschofski; Sarah Wild; James F Wilson; Loïc Yengo; D Timothy Bishop; Ingrid B Borecki; John C Chambers; L Adrienne Cupples; Abbas Dehghan; Panos Deloukas; Ghazaleh Fatemifar; Caroline Fox; Terrence S Furey; Lude Franke; Jiali Han; David J Hunter; Juha Karjalainen; Fredrik Karpe; Robert C Kaplan; Jaspal S Kooner; Mark I McCarthy; Joanne M Murabito; Andrew P Morris; Julia A N Bishop; Kari E North; Claes Ohlsson; Ken K Ong; Inga Prokopenko; J Brent Richards; Eric E Schadt; Tim D Spector; Elisabeth Widén; Cristen J Willer; Jian Yang; Erik Ingelsson; Karen L Mohlke; Joel N Hirschhorn; John Andrew Pospisilik; M Carola Zillikens; Cecilia Lindgren; Tuomas Oskari Kilpeläinen; Ruth J F Loos; Göteborgs universitet

doi:10.1038/ncomms10495

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu, Felix R Day, Stefan Gustafsson, Martin L Buchkovich, Jianbo Na, Veronique Bataille, Diana L Cousminer, Zari Dastani, Alexander W Drong, Tõnu Esko, …

Nature communications, Vol.7(1), pp.10495-10495

01/02/2016

DOI: https://doi.org/10.1038/ncomms10495

PMCID: PMC4740398

PMID: 26833246

Abstract

Adiposity - genetics

Animals

Drosophila melanogaster - genetics

Drosophila melanogaster - metabolism

Gene Expression Regulation - physiology

Gene Knockdown Techniques

Genetic Predisposition to Disease

Genome-Wide Association Study

Heart Diseases - genetics

Humans

Quantitative Trait Loci - genetics

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

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Title: New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Creators - without role: Yingchang Lu - Icahn School of Medicine at Mount Sinai
Felix R Day - University of Cambridge
Stefan Gustafsson - Science for Life Laboratory
Martin L Buchkovich - University of North Carolina at Chapel Hill
Jianbo Na - Icahn School of Medicine at Mount Sinai
Veronique Bataille - King's College London
Diana L Cousminer - University of Helsinki
Zari Dastani - McGill University
Alexander W Drong - Wellcome Centre for Human Genetics
Tõnu Esko - Broad Institute
David M Evans - University of Bristol
Mario Falchi - Imperial College London
Mary F Feitosa - Washington University in St. Louis
Teresa Ferreira - University of Oxford
Åsa K Hedman - Wellcome Centre for Human Genetics
Robin Haring - European University of Applied Sciences
Pirro G Hysi - King's College London
Mark M Iles - Cancer Research UK
Anne E Justice - University of North Carolina at Chapel Hill
Stavroula Kanoni - Queen Mary University of London
Vasiliki Lagou - University of Oxford
Rui Li - McGill University
Xin Li - Boston University
Adam Locke - University of Michigan–Ann Arbor
Chen Lu - Boston University
Reedik Mägi - Science Oxford
John R B Perry - MRC Epidemiology Unit
Tune H Pers - Broad Institute
Qibin Qi - Albert Einstein College of Medicine
Marianna Sanna - King's College London
Ellen M Schmidt - University of Michigan–Ann Arbor
William R Scott - Ealing Hospital NHS Trust
Dmitry Shungin - Lund University
Alexander Teumer - Greifswald University Hospital
Anna A E Vinkhuyzen - University of Queensland
Ryan W Walker - Icahn School of Medicine at Mount Sinai
Harm-Jan Westra - Brigham and Women's Hospital
Mingfeng Zhang - Brigham and Women's Hospital
Weihua Zhang - Imperial College London
Jing Hua Zhao - MRC Epidemiology Unit
Zhihong Zhu - University of Queensland
Uzma Afzal - Imperial College London
Tarunveer Singh Ahluwalia - Copenhagen Prospective Studies on Asthma in Childhood
Stephan J L Bakker - University of Groningen
Claire Bellis - Texas Biomedical Research Institute
Amélie Bonnefond - European Genomic Institute for Diabetes
Katja Borodulin - Finnish Institute for Health and Welfare
Aron S Buchman - Rush University Medical Center
Tommy Cederholm - Uppsala University
Audrey C Choh - Wright State University
Hyung Jin Choi - Seoul National University
Joanne E Curran - The University of Texas Rio Grande Valley
Lisette C P G M de Groot - Department of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
Philip L De Jager - Broad Institute
Rosalie A M Dhonukshe-Rutten - Wageningen University & Research
Anke W Enneman - Erasmus MC
Elodie Eury - University of Lille
Daniel S Evans - California Pacific Medical Center
Tom Forsen - University of Helsinki
Nele Friedrich - Greifswald University Hospital
Frédéric Fumeron - Centre de Recherche des Cordeliers
Melissa E Garcia - National Institute on Aging
Simone Gärtner - Greifswald University Hospital
Bok-Ghee Han - Korea National Institute of Health
Aki S Havulinna - Finnish Institute for Health and Welfare
Caroline Hayward - MRC Institute of Genetics and Molecular Medicine
Dena Hernandez - National Institute on Aging
Hans Hillege - University Medical Center Groningen
Till Ittermann - Greifswald University Hospital
Jack W Kent - Texas Biomedical Research Institute
Ivana Kolcic - University of Split
Tiina Laatikainen - University of Eastern Finland
Jari Lahti - University of Helsinki
Irene Mateo Leach - University Medical Center Groningen
Christine G Lee - Research Service, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
Jong-Young Lee - Korea National Institute of Health
Tian Liu - Max Planck Institute for Human Development
Youfang Liu - University of North Carolina at Chapel Hill
Stéphane Lobbens - University of Lille
Marie Loh - Imperial College London
Leo-Pekka Lyytikäinen - Fimlab
Carolina Medina-Gomez - Erasmus MC
Karl Michaëlsson - Uppsala University
Mike A Nalls - National Institute on Aging
Carrie M Nielson - Oregon Health & Science University
Laticia Oozageer - Ealing Hospital
Laura Pascoe - Newcastle University
Lavinia Paternoster - University of Bristol
Ozren Polašek - University of Split
Samuli Ripatti - Wellcome Sanger Institute
Mark A Sarzynski - Pennington Biomedical Research Center
Chan Soo Shin - Seoul National University
Nina Smolej Narančić - Institute for Anthropological Research
Dominik Spira - Charité - Universitätsmedizin Berlin
Priya Srikanth - Oregon Health & Science University
Elisabeth Steinhagen-Thiessen - Charité - Universitätsmedizin Berlin
Yun Ju Sung - Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Karin M A Swart - EMGO Institute for Health and Care Research
Leena Taittonen - University of Oulu
Toshiko Tanaka - National Institute on Aging
Emmi Tikkanen - University of Helsinki
Nathalie van der Velde - Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Natasja M van Schoor - VUMC, Department of Epidemiology and Biostatistics, 1081 BT Amsterdam, The Netherlands
Niek Verweij - University Medical Center Groningen
Alan F Wright - University of Edinburgh
Lei Yu - Rush University Medical Center
Joseph M Zmuda
Niina Eklund - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Terrence Forrester - Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica
Niels Grarup - University of Copenhagen
Anne U Jackson - University of Michigan–Ann Arbor
Kati Kristiansson - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Teemu Kuulasmaa - University of Eastern Finland
Johanna Kuusisto - Kuopio University Hospital
Peter Lichtner - Helmholtz Zentrum München
Jian'an Luan - University of Cambridge
Anubha Mahajan - University of Oxford
Satu Männistö - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Cameron D Palmer - Boston Children's Hospital
Janina S Ried - Helmholtz Zentrum München
Robert A Scott - University of Cambridge
Alena Stancáková - University of Eastern Finland
Peter J Wagner - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Ayse Demirkan - Erasmus MC
Angela Döring - Helmholtz Zentrum München
Vilmundur Gudnason - University of Iceland
Douglas P Kiel - Institute for Aging Research Hebrew Senior Life, Boston, Massachusetts 02131, USA
Brigitte Kühnel - Helmholtz Zentrum München
Massimo Mangino - King's College London
Barbara Mcknight - University of Washington
Cristina Menni - King's College London
Jeffrey R O'Connell - Genomic
Ben A Oostra - Erasmus MC
Alan R Shuldiner - Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21042, USA
Kijoung Song - GlaxoSmithKline
Liesbeth Vandenput - University of Gothenburg
Cornelia M van Duijn - Center for Medical Systems Biology, 2300 Leiden, The Netherlands
Peter Vollenweider - University Hospital of Lausanne
Charles C White - Boston University
Michael Boehnke - University of Michigan–Ann Arbor
Yvonne Boettcher - University of Leipzig, Department of Medicine, 04103 Leipzig, Germany
Richard S Cooper - Loyola University Chicago
Nita G Forouhi - University of Cambridge
Christian Gieger - Helmholtz Zentrum München
Harald Grallert - German Center for Diabetes Research
Aroon Hingorani - University College London
Torben Jørgensen - Capital Region of Denmark
Pekka Jousilahti - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Mika Kivimaki - Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK
Meena Kumari - Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK
Markku Laakso - Kuopio University Hospital
Claudia Langenberg - Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK
Allan Linneberg - Glostrup Hospital
Amy Luke - Loyola University Chicago
Colin A Mckenzie - University of the West Indies
Aarno Palotie - Massachusetts General Hospital
Oluf Pedersen - University of Copenhagen
Annette Peters - Helmholtz Zentrum München
Konstantin Strauch - Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany
Bamidele O Tayo - Loyola University Chicago
Nicholas J Wareham - University of Cambridge
David A Bennett - Rush University Medical Center
Lars Bertram - University of Lübeck
John Blangero - The University of Texas Rio Grande Valley
Matthias Blüher - University of Leipzig, Department of Medicine, 04103 Leipzig, Germany
Claude Bouchard - Pennington Biomedical Research Center
Harry Campbell - University of Edinburgh
Nam H Cho - Ajou University
Steven R Cummings - California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
Stefan A Czerwinski - Wright State University
Ilja Demuth - Charité - Universitätsmedizin Berlin
Rahel Eckardt
Johan G Eriksson - Folkhälsan Research Centre, FI-00290 Helsinki, Finland
Luigi Ferrucci - National Institute on Aging
Oscar H Franco - Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Philippe Froguel - Université de Lille
Ron T Gansevoort - University Medical Center Groningen
Torben Hansen - University of Southern Denmark
Tamara B Harris - National Institute on Aging
Nicholas Hastie - University of Edinburgh
Markku Heliövaara - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Albert Hofman - Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Joanne M Jordan - University of North Carolina at Chapel Hill
Antti Jula - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Mika Kähönen - University of Tampere
Eero Kajantie - Oulu University Hospital
Paul B Knekt - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Seppo Koskinen - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Peter Kovacs - IFB Adiposity Diseases
Terho Lehtimäki - University of Tampere
Lars Lind - Uppsala University
Yongmei Liu - Center for Human Genetics
Eric S Orwoll - Oregon Health & Science University
Clive Osmond - University of Southampton
Markus Perola - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Louis Pérusse - Université du Québec
Olli T Raitakari - University of Turku
Tuomo Rankinen - Pennington Biomedical Research Center
D C Rao - Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Treva K Rice - Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Fernando Rivadeneira - Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Igor Rudan - University of Edinburgh
Veikko Salomaa - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Thorkild I A Sørensen - Frederiksberg Hospital
Michael Stumvoll - University of Leipzig, Department of Medicine, 04103 Leipzig, Germany
Anke Tönjes - University of Leipzig, Department of Medicine, 04103 Leipzig, Germany
Bradford Towne - Wright State University
Gregory J Tranah - California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
Angelo Tremblay - Université du Québec
André G Uitterlinden - Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Pim van der Harst - University Medical Center Groningen
Erkki Vartiainen - National Institute for Health and Welfare, FI-00271 Helsinki, Finland
Jorma S Viikari - University of Turku
Veronique Vitart - University of Edinburgh
Marie-Claude Vohl - Université du Québec
Henry Völzke - DZD (German Centre for Diabetes Research), partner site Greifswald, 17475 Greifswald, Germany
Mark Walker - University of Newcastle Australia
Henri Wallaschofski - DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany
Sarah Wild - University of Edinburgh
James F Wilson - University of Edinburgh
Loïc Yengo - Université de Lille
D Timothy Bishop - University of Leeds
Ingrid B Borecki - Regeneron
John C Chambers - Imperial College Healthcare NHS Trust
L Adrienne Cupples - National Heart Lung and Blood Institute
Abbas Dehghan - Department of Epidemiology, Erasmus Medical Center, 3000CA Rotterdam/Zuidholland, The Netherlands
Panos Deloukas - King Abdulaziz University
Ghazaleh Fatemifar - University of Bristol
Caroline Fox - National Heart Lung and Blood Institute
Terrence S Furey - Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Lude Franke - University Medical Center Groningen
Jiali Han - Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA
David J Hunter - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Juha Karjalainen - University Medical Center Groningen
Fredrik Karpe - Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK
Robert C Kaplan - Albert Einstein College of Medicine
Jaspal S Kooner - Imperial College London
Mark I McCarthy - Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK
Joanne M Murabito - Boston University
Andrew P Morris - University of Liverpool
Julia A N Bishop - University of Leeds
Kari E North - University of North Carolina at Chapel Hill
Claes Ohlsson - University of Gothenburg
Ken K Ong - University of Cambridge
Inga Prokopenko - University of Oxford
J Brent Richards - McGill University
Eric E Schadt - Icahn School of Medicine at Mount Sinai
Tim D Spector - King's College London
Elisabeth Widén - University of Helsinki
Cristen J Willer - University of Michigan–Ann Arbor
Jian Yang - University of Queensland
Erik Ingelsson - Stanford University School of Medicine
Karen L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Joel N Hirschhorn - Harvard Medical School
John Andrew Pospisilik - Max Planck Institute of Immunobiology and Epigenetics
M Carola Zillikens - Genomics
Cecilia Lindgren - University of Oxford
Tuomas Oskari Kilpeläinen - University of Copenhagen
Ruth J F Loos - Icahn School of Medicine at Mount Sinai
Göteborgs universitet
Publication Details: Nature communications, Vol.7(1), pp.10495-10495
Grant note: Department of Health Wellcome Trust MC_UU_12015/5 / Medical Research Council British Heart Foundation MC_UU_12011/4 / Medical Research Council R01 DK072193 / NIDDK NIH HHS R01 AG027574 / NIA NIH HHS MR/J012165/1 / Medical Research Council MC_U147574242 / Medical Research Council Canadian Institutes of Health Research MC_UP_A620_1016 / Medical Research Council R01 HL117078 / NHLBI NIH HHS IK2 CX000729 / CSRD VA P30 DK020541 / NIDDK NIH HHS R01 DK106236 / NIDDK NIH HHS Arthritis Research UK 281641 / European Research Council MC_U106179471 / Medical Research Council MR/K002414/1 / Medical Research Council MC_UU_12011/3 / Medical Research Council P30 DK079637 / NIDDK NIH HHS Biotechnology and Biological Sciences Research Council Chief Scientist Office K01 AR062655 / NIAMS NIH HHS MR/J010642/1 / Medical Research Council MC_UU_12015/1 / Medical Research Council R01 DK093757 / NIDDK NIH HHS MC_U106179472 / Medical Research Council K01 HL129892 / NHLBI NIH HHS MR/K006584/1 / Medical Research Council R01 DK089256 / NIDDK NIH HHS MC_UU_12015/2 / Medical Research Council MR/K013351/1 / Medical Research Council MC_UP_A100_1003 / Medical Research Council R01 DK075787 / NIDDK NIH HHS U01 DK062370 / NIDDK NIH HHS P30 DK020572 / NIDDK NIH HHS MC_PC_U127561128 / Medical Research Council R01 AR041398 / NIAMS NIH HHS 10589 / Cancer Research UK P30 AG010161 / NIA NIH HHS MC_UU_12013/4 / Medical Research Council
Identifiers: 9937142008331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article