Abstract
Monkeypox (MPX) is a zoonotic illness that is analogous to smallpox. Monkeypox infections have moved across the forests of Central Africa, where they were first discovered, to other parts of the world. It is transmitted by the monkeypox virus, which is a member of the Poxviridae species and belongs to the Orthopoxvirus genus. In this article, the monkeypox virus is investigated using a deterministic mathematical framework within the Atangana-Baleanu fractional derivative that depends on the generalized Mittag-Leffler (GML) kernel. The system's equilibrium conditions are investigated and examined for robustness. The global stability of the endemic equilibrium is addressed using Jacobian matrix techniques and the Routh-Hurwitz threshold. Furthermore, we also identify a criterion wherein the system's disease-free equilibrium is globally asymptotically stable. Also, we employ a new approach by combining the two-step Lagrange polynomial and the fundamental concept of fractional calculus. The numerical simulations for multiple fractional orders reveal that as the fractional order reduces from 1, the virus's transmission declines. The analysis results show that the proposed strategy is successful at reducing the number of occurrences in multiple groups. It is evident that the findings suggest that isolating affected people from the general community can assist in limiting the transmission of pathogens.