Abstract
Three new phenolic glycosides (1-3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC5(0) 8.7 mu M. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC50 values of 11.3 mu M, 9.4 mu M, and 13.4 mu M, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines.